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Dr Elena Sviderskaya

Senior Lecturer in Cell and Molecular Biology
Elena Sviderskaya is a cell biologist working in the field of pigment cell and melanoma research.
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Overview

Elena Sviderskaya is a cell biologist working in the field of pigment cell and melanoma research.

She is Director of the Functional Genomics Cell Bank at St George's.

Recent publications:

  1. Woodcock E, Gorelkin PV, Goff PS, Edwards CRW, Zhang Y, Korchev Y and Sviderskaya EV. (2023) Measuring melanoma nanomechanical properties in relation to metastatic ability and anti-cancer drug treatment using Scanning Ion Conductance microscopy. Cells 12(19) 2401. https://doi.org/10.3390/cells12192401
  2. Goff PS, Castle JT, Kohli JS, Sviderskaya EV and Bennett DC. (2023) Isolation, culture, and transfection of melanocytes. Current Protocols, 3(5), e774. https://doi.org/10.1002/cpz1.774
  3. Sirés-Campos J, Lambertos A, Delevoye C, Raposo G, Bennett DC, Sviderskaya EV, Jiménez-Cervantes C, Olivares C and García-Borrón JC. (2022) Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells. Cell Mol Life Sci, 79, 47. doi: 1007/s00018-021-04053-9.
  4. Bowman S, Le L, Zhu Y, Harper DC, Sitaram A, Theos AC, Sviderskaya EV, Bennett DC, Raposo G, Owen DJ, Dennis MK and Marks MS. (2021) A BLOC-1:AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers. J Cell Biol 220, e202005173. doi 10.1083/jcb.202005173.
  5. Kolmogorov VS, Erofeev AS, Woodcock E, Efremov YM, Iakovlev AP, Savin NA, Alova AV, Lavrushkina SV, Kireev II, Prelovskaya A, Sviderskaya EV, et al. (2021) Mapping mechanical properties of living cells at nanoscale using intrinsic nanopipette-sample force interaction. Nanoscale 13, 6558-6568. https://pubs.rsc.org/en/Content/ArticleLanding/2021/NR/D0NR08349F#!divAbstract.
  6. Chen Q, Zhou D, Abdel-Malek Z, Zhang F, Goff PS, Sviderskaya EV, Wakamatsu K, Ito S, Gross S and Zippin JH. (2021) Measurement of melanin metabolism in live cells by [U-13C]-tyrosine fate tracing using LC-MS. J Invest Dermatol 141, 1810-1818.e6 doi: https://doi.org/10.1016/j.jid.2021.01.007.
  7. Le L, Escobar I, Ho T, Lefkovith A, Latteri E, Haltaufderhyde K, Dennis M, Plowright L, Sviderskaya EV, Bennett DC, Oancea E and Marks MS (2020) Melanosomal SLC45A2 regulates lumenal pH and pigmentation later during melanosome maturation than OCA2. Mol Biol Cell 31, 2687–2702. doi: 1091/mbc.E20-03-0200.
  8. Patel S, Wilkinson CJ and Sviderskaya EV (2020) Loss of both CDKN2A and CDKN2B allows for centrosome overduplication in melanoma. J Invest Dermatol 140(9): 1837–1846.e1. doi: 1016/j.jid.2020.01.024.
  9. Alzahofi N, Welz T, Robinson CL, Page EL, Briggs DA, Stainthorp AK, Reekes J, Elbe DA, Straub F, Kallemeijn WW, Tate EW, Goff PS, Sviderskaya EV, Cantero M, Montoliu L, Nedelec F, Miles AK, Bailly M, Keerkhoff E and Hume AN (2020) Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins. Nature Commun 11:3495. doi: 1038/s41467-020-17212-6.
  10. Zhang Y, Takahashi Y, Hong HP, Liu F, Bednarska J, Goff PS, Novak P, Shevchuk A, Gopal S, Barozzi IG, Magnani L, Sakai H, Suguru Y, Fujii T, Erofeev A, Gorelkin P, Majouga A, Weiss DJ, Edwards C, Ivanov A, Klenerman D, Sviderskaya EV*, Edel JB and Korchev YE (*co-corresponding author) (2019) High-resolution label-free mapping of extracellular pH of living cells. Nature Commun 10:5610. doi: 1038/s41467-019-13535-1.
  11. Sanzà P, Evans RD, Briggs DA, Cantero M, Montoliu L, Patel S, Sviderskaya EV, Itzen A, Figueiredo AC, Seabra MC and Hume AN. (2019) Nucleotide exchange factor Rab3GEP facilitates, but is not the sole determinant of, the specificity of Rab27a targeting. J Cell Sci. jcs.212035. doi: 10.1242/jcs.212035.
  12. Zhang Z, Gong J, Sviderskaya EV, Wei A, and Li W. (2019) Mitochondrial NCKX5 regulates melanosomal biogenesis and pigment production J Cell Sci. doi: 10.1242/jcs.232009.
  13. Zhang Y; Clausmeyer J; Babakinejad B; Lapez A; Ali T; Shevchuk A; Takahashi Y; Novak P; Edwards C; Lab M; Gopal S; Chiappini C; Anand U; Magnani L; Coombes C; Gorelik J; Matsue T; Schuhmann W; Klenerman D; Sviderskaya EV*; Korchev Y. (2016) Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis. (*co-corresponding author). ACS Nano 10, 3214-3221 PMID 26816294, https://pubs.acs.org/doi/abs/10.1021/acsnano.5b05211
  14. Dennis MK, Delevoye C, Acosta-Ruiz A, Hurbain I, Romao M, Hesketh GG, Goff PS, Sviderskaya EV, Bennett DC, Luzio JP, Galli T, Owen DJ, Raposo G and Marks MS (2016) BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers. J Cell Biol, 214, 293-308 PMID 27482051, http://jcb.rupress.org/content/214/3/293.short
  15. Cao J, Dai X, Wan L, Wang H, Zhang J, Goff PS, Sviderskaya EV, Xuan Z, Xu Z, Xu X, Hinds P, Flaherty KT, Faller DV, Goding CR, Wang Y, Wei W, Cui R. (2015) The E3 ligase APC/CCdh1 promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth. Sci Signal 8(392):ra87 DOI: 10.1126/scisignal.aab1995 http://stke.sciencemag.org/content/8/392/ra87.abstract
  16. Fufa TD, Harris ML, Watkins-Chow DE, Levy D, Gorkin DU, Gildea DE, Song L, Safi A, Crawford GE, Sviderskaya EV, Bennett DC, Mccallion AS, Loftus SK, Pavan WJ. (2015) Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes. Hum Mol Genet 24(19):5433-5450 PMID 26206884 https://academic.oup.com/hmg/article/24/19/5433/583807
  17. Dennis MK, Mantegazza AR, Snir OL, Tenza D, Acosta-Ruiz A, Delevoye C, Zorger R, Sitaram A, de Jesus-Rojas W, Ravichandran K, Rux J, Sviderskaya EV, Bennett DC, Raposo G, Marks MS, Setty SR. (2015) BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery. J Cell Biol 209(4):563-577 PMID 26008744, http://jcb.rupress.org/content/209/4/563.short
  18. Evans RD, Robinson C, Briggs DA, Tooth DJ, Ramalho JS, Montoliu L, Sviderskaya EV and Hume AN (2014) Myosin-Va and actin dynamics oppose microtubule based transport to drive organelle dispersion Current Biology 24:1743-1750 PMID 25065759, https://www.sciencedirect.com/science/article/pii/S0960982214007337
  19. Actis P, Tokar S, Clausmeyer J, Babakinejad B, Mikhaleva S, Cornut R, Takahashi Y, Córdoba LA, Novak P, Shevchuck A, Dougan JA, Kazarian SG, Gorelkin P, Erofeev AS, Yaminsky IV, Unwin PR, Schuhmann W, Klenerman D, RusakovDA, Sviderskaya EV and Korchev YE (2014) Electrochemical nanoprobes for single-cell analysis. ACS Nano 8:875-884 DOI: 1021/nn405612q, https://pubs.acs.org/doi/abs/10.1021/nn405612q
  20. Redmond RW, Rajadurai A, Udayakumar D, Sviderskaya EV and Tsao H (2014) Melanocytes are selectively vulnerable to UVA-mediated bystander oxidative signaling. J Invest Dermatol 134:1083-1090 PMID 24335898, https://www.sciencedirect.com/science/article/pii/S0022202X15367130
  21. Lobos-Gonzalez L, Aguilarguzmán L, Fernandez JG, Muñoz N, Hossain M, Bieneck S, Silva V, Burzio V, Sviderskaya EV, BennettDC, Leyton L and Quest AFG (2014) Caveolin-1 is a risk factor for post-surgery metastasis in preclinical melanoma models. Melanoma Res 24:108-119 PMID 24500501, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999137/
  22. Lam RYY, Lin Z-X, Sviderskaya EV and Cheng CHK (2014) Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions. Int J Mol Sci 15:14649-14668 PMID 25196602, https://www.mdpi.com/1422-0067/15/8/14649
  23. Lu, M., Breyssens, H., Salter, V., Zhong, S., Hu, Y., Baer, C., Ratnayaka, I., Sullivan, A., Brown, N.R., Endicott, J., Knapp, S., Kessler, B.M., Middleton, M.R.,Siebold, C., Jones, E.Y., Sviderskaya, E.V., Cebon, J., John, T., Caballero, O.L., Goding, C.R. and Lu, X. (2013) Restoring p53 function in human melanoma cells by Inhibiting MDM2 and Cyclin B1/CDK1-phosphorylated nuclear iASPP. Cancer Cell 23:618-633 DOI: 1016/j.ccr.2013.03.013, https://www.sciencedirect.com/science/article/pii/S153561081300127X
  24. Huang, Z.-M., Chinen, M., Chang, P., Sviderskaya, E.V., Bennett, D.C., Millhauser, G. and Wei, M.L. (2012) Targeting protein-trafficking pathways alters melanoma treatment sensitivity. Proc Natl Acad Sci USA 109:553-558 PMID 22203954, https://www.pnas.org/content/109/2/553.short
  25. Sitaram, A., Chaudhuri, R., De Jesus-Rojas, W., Tenza, D., Setty, S.G., Sviderskaya, E.V., Bennett, D.C., Raposo, G., Bonifacino, J.S. and Marks, M.S. (2012) Differential sequence preferences for AP-1 and AP-3 in an acidic dileucine-based sorting signal reveal a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes. Mol Biol Cell 23:3178-3192 PMID 22718909, https://www.molbiolcell.org/doi/full/10.1091/mbc.e11-06-0509
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