Selected publications
Enhanced MC1R-signalling and pH modulation facilitate melanogenesis within late endosomes of BLOC-1-deficient melanocytes. Philip S. Goff, Shyamal Patel, Tom Carter, Michael S. Marks, Elena V. Sviderskaya. (2024). biorxiv, https://www.biorxiv.org/content/10.1101/2024.07.08.602505v1
A new look at an old body: molecular determinants of Weibel-Palade body composition and VWF exocytosis. Hordijk S, Carter T, Bierings R. (2024) J Thromb Haemost. S1538-7836 (24)00055-2. doi: 10.1016/j.jtha.2024.01.015. Epub ahead of print. PMID: 38307391.
Ca2+-Dependent and-Independent Calmodulin Binding to the Cytoplasmic Loop of Gap Junction Connexins. Tran, O.; Kerruth, S.; Coates,C.; Kaur, H.; Peracchia, C.; Carter, T.; K. Török. (2023) Int. J. Mol. Sci, 24, 4153. https://doi.org/ 10.3390/ijms24044153
Altered Storage and Function of von Willebrand Factor in Human Cardiac Microvascular Endothelial Cells Isolated from Recipient Transplant Hearts. Meli, A.; McCormack, A.; Conte, I.; Chen, Q.; Streetley, J.; Rose, M.L.; Bierings, R.; Hannah, M.J.; Molloy, J.E.; Rosenthal, P.B. Carter, T (2023). Int. J. Mol. Sci. 2023, 24, 4553.https://doi.org/10.3390/ijms24054553
Quantitative super-resolution imaging of platelet degranulation reveals differential release of VWF and VWF propeptide from alpha-granules. Swinkels M, Hordijk S, Bürgisser PE, Slotman JA, Carter TD, Leebeek FWG, Jansen AJG, Voorberg J, Bierings R. (2023) J Thromb Haemost, 21 (7). pp. 1967-1980. ISSN 1538-7836 https://doi.org/10.1016/j.jtha.2023.03.041 .
Development and optimisation of genetically encoded calcium sensors. Oanh Tran, Holly J. Hughes, Tom Carter, Katalin Török (2023). Front Cell Neurosci:17:1155406. doi: 10.3389/fncel.2023.1155406. eCollection 2023.
P-selectin mobility undergoes a sol-gel transition as it diffuses from exocytosis sites into the cell membrane. Hellen N, Mashanov GI, Conte IL, le Trionnaire S, Babich V, Knipe L, Mohammed A, Ogmen K, Martin-Almedina S, Török K, Hannah MJ, Molloy JE, Carter T. (2022) Nat Commun.13(1):3031. doi: 10.1038/s41467-022-30669-x. PMID: 35641503
GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies. Marije Kat, Petra E. Bürgisser, Hans Janssen, Iris M. De Cuyper, Ianina Conte, Alistair N. Hume, Tom Carter, Jan Voorberg, Coert Margadant and Ruben Bierings (2021). Blood Advances 5(23):5116-5127.doi: 10.1182/bloodadvances.2021004827. PMID:34551092
Stimulated release of intraluminal vesicles from Weibel-Palade bodies. Streetley J, Fonseca AV, Turner J, Kiskin NI, Knipe L, Rosenthal PB, Carter T. (2019). Blood. 133(25):2707-2717.doi: 10.1182/blood-2018-09-874552. Epub 2019 Feb 13. PMID: 30760452
WPBs: making a mark and leaving a trail. Carter T, Bierings R. (2019) Blood;134(12):909-910. doi: 10.1182/blood.2019002322. PMID: 31537537PMID: 34551092 Free PMC article.
Synaptotagmin 5 regulates calcium-dependent Weibel-Palade body exocytosis in human endothelial cells. Camille Lenzi, Jennifer Stevens, Daniel Osborn, Matthew J. Hannah, Ruben Bierings, and Tom Carter. J cell Sci (2019). PMID: 30659119
Weibel-Palade Body Localized Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial Cells. Schillemans M, Karampini E, van den Eshof BL, Gangaev A, Hofman M, van Breevoort D, Meems H, Janssen H, Mulder AA, Jost CR, Escher JC, Adam R, Carter T, Koster AJ, van den Biggelaar M, Voorberg J, Bierings R. (2018). Arterioscler Thromb Vasc Biol. 38(7):1549-1561. PMID: 29880488.
Interaction between MyRIP and the actin cytoskeleton regulates Weibel-Palade body trafficking and exocytosis. Conte IL, Hellen N, Bierings R, Mashanov GI, Manneville JB, Kiskin NI, Hannah MJ, Molloy JE, Carter T.(2016). J Cell Sci. 129(3):592-603.PMID: 26675235
Is there more than one way to unpack a Weibel-Palalde body? Conte IL, Cookson EA, Hellen N, Bierings R, Mashanov, G, Carter T. (2015). Blood 126(18):2165-7. DOI 10.1182/blood-2015-08-664961. PMID: 26377598
STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a. Dorothee van Breevoort et al. (2014). Blood. 123(20):3185-94. PMID 24700782
The interplay between the Rab27A effectors Slp4 a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis. Bierings R, Hellen N, Kiskin N, Knipe L, Fonseca AV, Patel B, Meli A, Rose M, Hannah MJ, Carter T. (2012). Blood. 120: 2757-2767. PMID 22898601
Structural organization of Weibel-Palade bodies revealed by cryo-EM of vitrified endothelial cells. Berriman JA, Li S, Hewlett LJ, Wasilewski S, Kiskin FN, Carter T, Hannah MJ, Rosenthal PB (2009). Proc Natl Acad Sci U S A, 106, 17407-17412. PMID 19805028
Selective release of molecules from Weibel Palade bodies during a lingering kiss. Babich V, Meli A, Knipe L, Dempster JE, Skehel P, Hannah MJ, Carter T. (2008). Blood, 111:5282-5290. PMID 18252862 (Plenary paper).
Internal
Prof. Katalin Török (MCS Section, City St Georges U of L).
Prof. Guy Whitley (Cardiovascular & Genetics RI, City St Georges U of L)
Dr Daniel Osborne (Genetics Research Section, City St Georges U of L).
Dr Soo-Hyun Kim (MCS Section, City St Georges U of L)
Dr Suman Rice (MCS Section, City St Georges U of L).
External
Dr Ruben Bierings, (Department of Hematology, Cancer Institute, Erasmus MC, Rotterdam, Netherlands). Trafficking and secretions in the vasculature. https://www.erasmusmc.nl/en/cancer-institute/research/groups/hematology-bierings-lab
Dr Paul Skehel (Center for Intergrative Physiology, University of Edinburgh). P-selectin trafficking and secretion; http://www.ed.ac.uk/integrative-physiology/staff-profiles/research-groups/paul-skehel
Dr Justin Molloy, (Crick Institute Mill Hill Laboratory, London). Molecular motors and single molecule imaging. https://www.crick.ac.uk/research/a-z-researchers/researchers-k-o/justin-molloy/
Dr Peter Rosenthal, (Crick Institute Mill Hill Laboratory, London). Structural studies of endothelial cells and their secretory granules; https://www.crick.ac.uk/research/a-z-researchers/researchers-p-s/peter-rosenthal/
Dr John Dempster (University of Strathclyde). Development of imaging and electrophysiology software and instrumentation; http://www.strath.ac.uk/staff/dempsterjohndr/
Professor Caroline Wheeler-Jones (Royal Veterinary College, London). Endothelial Cell Biology http://www.rvc.ac.uk/about/our-people/caroline-wheeler-jones
Dr Elizabeth Findings (Royal Veterinary College, London). Equine Endothelial Cell Biology. https://www.rvc.ac.uk/about/our-people/liz-finding
Dr Matthew Hannah Dr Matthew Hannah (Microbiology Services Division Colindale, Public Health England, London). EM and cell biology of secretory pathway. https://www.researchgate.net/profile/Matthew_Hannah