Professor Ian Loftus is a Consultant in Vascular Surgery and Honorary Senior Lecturer. He is actively involved in vascular research, teaching and training. He is the Director of the St George's regional aneurysm screening programme and Care Group Lead for the St George's Vascular Institute.
His major area of research is the investigation of factors which lead to atherosclerotic plaque instability. Unstable plaques are responsible for most of the clinical sequelae of atherosclerosis. He has a particular interest in the role of proteolytic enzymes in carotid plaque morphology and aneurysms. Subsequently his group has performed clinical trials of pharmacological agents which have been published in the journals ‘Circulation’ and ‘Stroke’. They have an active scientific research programme and a clinical research unit, involved in a number of clinical trials.
Professor Loftus's interest in vascular biology began more than 10 years ago.
He is the critical care tutor for the Royal College of Surgeons of England, and a member of the Royal College Court of Examiners. He has previously been a member of the Steering Group on SHO Workforce Planning, part of the National Health Service ‘Changing Workforce Programme’. He was also Membership and Organisational Secretary of the Rouleaux Club (Vascular surgical trainees of Great Britain) from 2001 to 2003, a Committee Member of the Association of Surgeons in Training for three years and a member of the South Trent Regional Surgical Training Committee.
Honours and awards
The Association of Surgeons of Great Britain ‘Moynihan’ Prize
The Vascular Society of Great Britain ‘British Journal of Surgery’ Scientific Prize
The Vascular Society of Great Britain Founders’ Clinical Prize
Loftus IM, Naylor AR, Goodall S, Crowther M, Jones L, Bell PRF, Thompson MM. Increased MMP-9 Activity in Unstable Carotid Plaques. Stroke 2000; 31: 40-47
Axisa B, Loftus IM, Naylor AR, Goodall S, Jones L, Bell PRF and Thompson MM. A prospective randomised double blinded trial investigating the effect of doxycycline on matrix metalloproteinase expression within atherosclerotic carotid plaques. Stroke 2002,33:2858-64.
KJ Molloy, MM Thompson, JL Jones, EC Schwalbe, PRF Bell, AR Naylor, IM Loftus. Unstable Carotid Plaques Exhibit Raised MMP-8 Activity. Circulation 2004; 110: 337-343
The Royal College of Surgeons of England
Professor Loftus has had involvement in the organisation, delivery and assessment of undergraduate and postgraduate medical education, and the teaching of undergraduates in Biochemistry and Pharmacology.