Dr Copeland is currently a Lecturer in Neuropharmacology at the Institute of Medical and Biomedical Education at St George’s.
Dr Copeland is currently setting up her first research lab focussing upon mechanisms of thalamocortical synchrony. She is interested in the neuronal mechanisms that underlie synchronous activity in the thalamus, cortex, and massively interconnected thalamocortical system. These mechanisms underlie multimodal processes ranging from sensory perception, to cognition and attention. Her approach will be to analyse the discrete components that make up thalamic and cortical circuits using both in vitro and in vivo electrophysiology approaches, and optogenetics.
Dr Copeland completed a PhD (University College London) in Neuropharmacology in 2013, followed by two years as a postdoctoral research associate (Imperial College London) developing 2 Photon calcium imaging strategies in sensory cortex.
Dr Copeland has published several research articles, reviews and book chapters, including publications in The Journal of Physiology, Neuropsychopharmacology and Neuropharmacology. She has also attracted funding from the Royal Society to commence her research.
Dr Copeland is joint module leader (with Dr Bailey) for the 'CNS and Mental Health' module for the Pharmacy MPharm course run jointly with Kingston University. She is co-module leader for 'Physiology and Pharmacology of Drugs of Abuse' in Year 3 of the Biomedical Science BSc. She also teaches neuropharmacology to medical students (USMLE) and on a Year 3 Clinical Neuroscience module on the BSc Biomedical Science course. She runs Scenario Based Learning tutorials throughout the year to Biomedical and Pharmacy students.
Dr Copeland is a responsible examiner for the Biomedical Science BSc, and she supervises undergraduate and Masters students. She is a Fellow of the Higher Education Academy and is studying for a Postgraduate Certificate in Higher Education.
Dr Copeland specialises in teaching neuropharmacology and neuroscience. In addition to teaching at St George’s, she has given invited lectures at Massachusetts Institute of Technology (MIT), Boston, USA; University of Lausanne, Switzerland; Paris Descartes University, France; University College London (UCL) and Imperial College, among others. She holds visiting lectureship positions at Florida State University and Kingston University.
1. Salt TE and COPELAND CS (2016). Metabotropic glutamate receptor function in thalamocortical circuitry. mGlu Receptors, New York, NY: Springer (eds. Nicoletti, Ngomba, Battaglia, and Di Giovanni).
2. Reynolds S, COPELAND CS, Schultz SR and Dragotti PL (2016). An extension of the FRI framework for calcium transient detection. Engineering in Medicine and Biology Society (EMBS), 38th Annual International Conference of the IEEE (in press).
3. Schuck R, Quicke P, COPELAND CS, Garasto S, Annechino LA, Hwang JK, Schultz SR (2015). Rapid three dimensional two photon neuronal population scanning. Engineering in Medicine and Biology Society (EMBS), 37th Annual International Conference of the IEEE, pp5867-5870.
4. Reynolds S, Onativia J, COPELAND CS, Schultz SR and Dragotti PL (2015). Spike detection using FRI methods and protein calcium sensors: performance analysis and comparisons. 11th International Conference on Sampling Theory and Applications (SampTA 2015), pp 533-537.
5. Fazio F, Lionetto L, Curto M, Iacovelli L, COPELAND CS , Neale SA, Bruno V, Battaglia G, Salt TE and Nicoletti F (2016). Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors. Neuropharmacology, doi: 10.1016/j.neurophar.2016.06.020
6. SR Schultz, C COPELAND, A Foust, P Quicke and R Schuck (2016). Advances in two photon scanning and scanless microscopic technologies for imaging neural circuits. Proceedings of the IEEE, doi: http://dx.doi.org/10.1101/036632
1. COPELAND CS, Neale SA and Salt TE (2015). Neuronal Activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors. Neuropharmacology, 92:16-24.
2. Neale SA, COPELAND CS, Uebele V, Thomson F and Salt TE (2013). Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid. Neuropsychopharmacology, 38:1060-1067.
3. COPELAND CS, Neale SA and Salt TE (2012). Positive allosteric modulation reveals a specific role for mGlu2 receptors in sensory processing in the thalamus. Journal of Physiology, 590: 937-951.
Professor Thomas Salt, University College London
Dr Rhein Parri, Aston University
Professor Ferdinando Nicoletti, University of Rome
Dr Amanda Foust, Imperial College London
Dr Simon Schultz, Imperial College London
Merck & Co.
Eli Lilly & Co.
2016-2018 Copeland (PI)
Can cortical Layer 6 activity be augmented to ameliorate schizophrenia?
The Royal Society; £15,000
Dr Copeland has made significant contributions to research in identifying the role of Group II metabotropic glutamate receptors in sensation. Activation of these receptors is thought to facilitate sensory discrimination, enabling important information to be discerned from background activity - for example, being able to hear a single person talk at a noisy party.
Dr Copeland is about to embark on a new line of investigation, examining pathophysiological activity in the cortex that is associated with psychiatric disease: which mechanisms may be responsible for this detrimental activity, and how they can be addressed therapeutically.
Dr Copeland's laboratory is also collaborating with Dr Amanda Foust, Royal Society of Engineering Fellow at Imperial College London, to adapt and optimise a two-photon light shaping method for brain circuit reverse engineering.