Biography
I am Professor of Molecular Parasitology and Medicine at St. George's University of London. After completing a degree at Cambridge and medical degree at Oxford, I studied malaria in Thailand before completing a DPhil at the Weatherall Institute of Molecular Medicine in Oxford. I joined St George’s in 2000. I was an MRC Training Fellow and Wellcome Trust Senior Research Fellow in Clinical Science (1994–2001). I was elected a Fellow of the Academy of Medical Sciences in 2004 and awarded an ScD by the University of Cambridge in 2007. I am also an honorary consultant physician in infectious disease and medicine at St George’s University Hospitals NHS Foundation Trust. I have been an advisor to multiple international bodies, including the World Health Organisation, and have sat on advisory committees for WHO and major international funders including the US National Institutes of Health, the UK’s Wellcome Trust and others. I chair the Infectious Disease Advisory Committee of QuantuMDx and I am an advisor to the Foundation for Innovative New Diagnostics (FIND), a not-for-profit organisation promoting the development of new diagnostic tools for resource-poor countries. I also have strong industrial contacts, and have acted as scientific advisor to several large pharmaceutical companies and biotech firms.
Key publications
Krishna S et al. A family of cation ATPase-like molecules from Plasmodium falciparum. J Cell Biol. 1993;120:385–98. PMID: 8421054
ter Kuile F, White NJ, Holloway PAH, Pasvol G, Krishna S. Pharmacodynamic properties of drugs used for the treatment of severe malaria assessed in vitro. Exp Parasitol. 1993;76:85–95. PMID: 8467901
Krishna S et al. Lactic acidosis and hypoglycaemia in severe malaria: pathophysiological and prognostic significance. Trans R Soc Trop Med Hyg. 1994;88:67–73. PMID: 8154008
Woodrow CJ, Penny JI, Krishna S. Intraerythrocytic Plasmodium falciparum expresses a high-affinity facilitative hexose transporter. J Biol Chem. 1999;274: 7272–7. PMID: 10066789
Joët T, Eckstein-Ludwig U, Morin C, Krishna S. The hexose transporter of Plasmodium falciparum is a novel drug target. Proc Natl Acad Sci USA. 2003;100:7476–9. PMID: 12792024
Eckstein-Ludwig U et al. Artemisinins target the SERCA of Plasmodium falciparum. Nature.2003;424:957–61. PMID: 12931192
Price RN et al. Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet. 2004;364:438–47. PMID: 15288742
Uhlemann A-C et al. A single amino acid can determine sensitivity of SERCAs to artemisinins. Nat Struct Mol Biol. 2005;12:628–9. PMID: 15937493
Gomes MF et al. Pre-referral rectal artesunate to prevent death and disability in severe malaria: placebo-controlled trial. Lancet. 2009;373:557–66. PMID: 19059639
Pulcini S et al. Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes. J Infect Dis. 2013;208(3):468–78. PMID: 23599312