Biography
I am a PhD student, evaluating the mechanisms of drug resistance in leukaemia emphasizing on the metabolic symbiotic nature of the malignant cells and to target them therapeutically under the guidance of Prof.Vikram Mathews, CMC, India. I joined Prof. Krishna's laboratory as newton-Bhabha PhD Placement student to evaluate the anti cancer potential of artemisinins in combination with conventional chemotherapeutic agents and also to identify the pleiotropic effects of antimalarials mechanistically by employing proteomic and metabolomics approaches.
Key publications
Metabolic Rewiring Drives Resistance to Arsenic Trioxide in Acute Promyelocytic Leukemia. Nithya Balasundaram, Saravanan Ganesan, Hamenth Kumar Palani, Ansu Abu Alex, Sachin David, Anu Korula, Biju George, Christine Chomienne, Poonkuzhali Balasubramanian, Vikram Mathews. Blood Dec 2016, 128 (22) 3956; American Society of Haematology 2016
Arsenic Trioxide Enhances the NK Cell Cytotoxicity Against Acute Promyelocytic Leukemia While Simultaneously Inhibiting Its Bio-Genesis. Ansu Abu Alex, Saravanan Ganesan, Hamenth Kumar Palani, Nithya Balasundaram, Sachin David, Kavitha M. Lakshmi, Uday P. Kulkarni, P. N. Nisham, Anu Korula, Anup J. Devasia, Nancy Beryl Janet, Aby Abraham, Alok Srivastava,,Biju George, Rose Ann Padua, Christine Chomienne, Poonkuzhali Balasubramanian,and Vikram Mathews. Front Immunol. 2018; 9: 1357.
Rationale and efficacy of proteasome inhibitor combined with arsenic trioxide in the treatment of acute promyelocytic leukemia. S Ganesan, A A Alex, E Chendamarai, N Balasundaram, H K Palani, S David, U Kulkarni, M Aiyaz, R Mugasimangalam, A Korula, A Abraham, A Srivastava, R A Padua, C Chomienne, B George, P Balasubramanian & V Mathews Leukemia volume 30, pages 2169–2178 (2016)