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Koech A, Mwaniki I, Mutunga J, Mukhanya M, Mwadime E, Ochieng M, Mwashigadi G, Mistry HD, Craik R, von Dadelszen P, Temmerman M, Luchters S, Omuse G; PRECISE Network. Diagnostic accuracy of a non-invasive spot-check hemoglobin meter, Masimo Rad-67® pulse CO-Oximeter®, in detection of anemia in antenatal care settings in Kenya. Front Glob Womens Health. 2024 Oct 14, PMID: 39469077
Moss S, Jones RT, Pretorius E, da Silva ET, Higgins M, Kristan M, Acford-Palmer H, Collins EL, Rodrigues A, Krishna S, Clark TG, Last A, Campino S. Phenotypic evidence of deltamethrin resistance and identification of selective sweeps in Anopheles mosquitoes on the Bijagós Archipelago, Guinea-Bissau. Sci Rep. 2024 Oct 1, PMID: 39354094
Moss S, Pretorius E, Ceesay S, da Silva ET, Hutchins H, Ndiath MO, Acford-Palmer H, Collins EL, Higgins M, Phelan J, Jones RT, Vasileva H, Rodrigues A, Krishna S, Clark TG, Last A, Campino S. Whole genome sequence analysis of population structure and insecticide resistance markers in Anopheles melas from the Bijagós Archipelago, Guinea-Bissau. Parasit Vectors. 2024 Sep. PMID: 39294791
Gazeley U, Ochieng MC, Wanje O, Koech Etyang A, Mwashigadi G, Barreh N, Kombo AM, Bakari M, Maitha G, Silverio SA, Temmerman M, Magee L, von Dadelszen P, Filippi V; PRECISE Network. Postpartum recovery after severe maternal morbidity in Kilifi, Kenya: a grounded theory of recovery trajectories beyond 42 days. BMJ Glob Health. 2024 Jun. PMID: 38925665
Achan J, Barry A, Leroy D, Kamara G, Duparc S, Kaszubska W, Gandhi P, Buffet B, Tshilab P, Ogutu B, Taylor T, Krishna S, Richardson N, Ramachandruni H, Rietveld H. Defining the next generation of severe malaria treatment: a target product profile. 2024 Jun. PMID: 38835069
Webb S, Mat Ali N, Sawyer A, Clark DJ, Brown MA, Augustin Y, Woo YL, Khoo SP, Hargreaves S, Staines HM, Krishna S, Hayes K. Patient preference and acceptability of self-sampling for cervical screening in colposcopy clinic attenders: A cross-sectional semi-structured survey. PLOS Glob Public Health. 2024 May. PMID: 38781145
Bertran-Cobo C, Dumont E, Noordin NR, Lai MY, Stone W, Tetteh KK, Drakeley C, Krishna S, Lau YL, Wassmer SC. Plasmodium knowlesi infection is associated with elevated circulating biomarkers of brain injury and endothelial activation. medRxiv. 2024 Apr. PMID: 38712121
Moss S, Pretorius E, Ceesay S, Hutchins H, da Silva ET, Ndiath MO, Jones RT, Vasileva H, Phelan J, Acford-Palmer H, Collins E, Rodrigues A, Krishna S, Clark TG, Last A, Campino S.Parasit Vectors. Genomic surveillance of Anopheles mosquitoes on the Bijagós Archipelago using custom targeted amplicon sequencing identifies mutations associated with insecticide resistance. 2024 Jan. PMID: 38178249
Koech A, Omuse G, Mugo AG, Mwaniki IG, Mutunga JM, Mukhanya MW, Wanje O, Mwashigadi GM, Katana GG, Craik R, von Dadelszen P, Le Doare K, Temmerman M; periCOVID-Africa; PRECISE Network.FSARS-CoV-2 seroprevalence in pregnant women in Kilifi, Kenya from March 2020 to March 2022. Front Public Health. 2023 Dec. PMID: 38169905
Huttner A, Agnandji ST, Engler O, Hooper JW, Kwilas S, Ricks K, Clements TL, Jonsdottir HR, Nakka SS, Rothenberger S, Kremsner P, Züst R, Medaglini D, Ottenhoff T, Harandi AM, Siegrist CA; VEBCON; VSV-EBOVAC; VSV-EBOPLUS Consortia. Antibody responses to recombinant vesicular stomatitis virus-Zaire Ebolavirus vaccination for Ebola virus disease across doses and continents: 5-year durability. Clin Microbiol Infect. 2023 DecClin Microbiol Infect. 2023 Dec. PMID: 37661067
Chen J, Gao P, Xiao W, Cheng G, Krishna S, Wang J, Wong YK, Wang C, Gu L, Yang DH, Wang J.Multi-omics dissection of stage-specific artemisinin tolerance mechanisms in Kelch13-mutant Plasmodium falciparum. Drug Resist Updat. 2023 Sep. PMID: 37385107
Caffry J, Selby M, Barr K, Morgan G, McGurk D, Scully P, Park C, Caridis AM, Southworth E, Morrison J, Clark DJ, Davies BMO, Eckersley NM, Groppelli E, Kirwan DE, Monahan I, Augustin Y, Toombs C, Planche T, Staines HM, Krishna S. The QuantuMDx Q-POC SARS-CoV-2 RT-PCR assay for rapid detection of COVID-19 at point-of-care: preliminary evaluation of a novel technology. Sci Rep. 2023 Jun. PMID: 37330592
Simões R, Augustin Y, Gulliford S, Dehbi HM, Hoskin P, Miles E, Harrington K, Miah AB. Toxicity, normal tissue and dose-volume planning parameters for radiotherapy in soft tissue sarcoma of the extremities: a systematic review of the literature.Radiother Oncol. 2023 Jun .PMID: 37315584
Augustin Y, Staines HM, Velavan TP, Kamarulzaman A, Kremsner PG, Krishna S. Drug repurposing for COVID-19: current evidence from randomized controlled adaptive platform trials and living systematic reviews. Br Med Bull. 2023 Jun. PMID: 37312588
Moss S, Mańko E, Vasileva H, Da Silva ET, Goncalves A, Osborne A, Phelan J, Rodrigues A, Djata P, D'Alessandro U, Mabey D, Krishna S, Last A, Clark TG, Campino S. Population dynamics and drug resistance mutations in Plasmodium falciparum on the Bijagós Archipelago, Guinea-Bissau.Sci Rep. 2023 Apr. PMID: 37072433
Augustin Y, Zaidi S, Jones RL, Benson C, Simcock R, Fisher C, Thway K, Hallin M, Miah AB. Biphenotypic Sinonasal Sarcoma: Case Reports of Diagnostic Findings and Clinical Management of 3 Cases. Anticancer Res. 2023 Apr. PMID: 36974788
Lau DK, Aresu M, Planche T, Tran A, Lazaro-Alcausi R, Duncan J, Kidd S, Cromarty S, Begum R, Rana I, Li S, Mohamed AA, Monahan I, Clark DJ, Eckersley N, Staines HM, Groppelli E, Krishna S, Mayora-Neto M, Temperton N, Fribbens C, Watkins D, Starling N, Chau I, Cunningham D, Rao S. SARS-CoV-2 Vaccine Immunogenicity in Patients with Gastrointestinal Cancer Receiving Systemic Anti-Cancer Therapy.Oncologist. 2023 Jan. PMID: 36342104
Angela Koech, Peris Muoga Musitia, Grace Mkanjala Mwashigadi, Mai-Lei Woo Kinshella, Marianne Vidler, Marleen Temmerman, Rachel Craik, Peter von Dadelszen , J Alison Noble, Aris T Papageorghiou ; PRECISE Network Collaborators, Acceptability and Feasibility of a Low-Cost Device for Gestational Age Assessment in a Low-Resource Setting: Qualitative Study, JMIR Hum Factors. 2022 Dec.PMID: 36574278
Martina Cusinato , Linda Hadcocks , Simon Yona, Timothy Planche, Derek Macallan, Increased monocyte distribution width in COVID-19 and sepsis arises from a complex interplay of altered monocyte cellular size and subset frequency,Int J Lab Hematol. 2022 Dec. PMID: 35915915
WHO Guidelines for malaria, 25 November 2022. Geneva: World Health Organization; 2022 (WHO/UCN/GMP/2022.01 Rev.3). License: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data. CIP data are available at http://apps.who.int/iris.Members of the GDG (2022)Achu D, Barnes K, Bart-Plange C, Dondorp A, Krishna S, (Co-chair) Lacerda M, Laufer M, Leke R, Mokuolu O, (Co-chair) Ogutu B, Rogerson S, Rosenthal P, Taylor T,
Kinshella MW, Omar S, Scherbinsky K, Vidler M, Magee LA, von Dadelszen P, Moore SE, Elango R; PRECISE Conceptual Framework Working Group. Maternal nutritional risk factors for pre-eclampsia incidence: findings from a narrative scoping review. Reprod Health. 2022 Sep, PMID: 36064716
Moss S, Mańko E, Krishna S, Campino S, Clark TG, Last A. How has mass drug administration with dihydroartemisinin-piperaquine impacted molecular markers of drug resistance? A systematic review; Malar J. 2022 Jun, PMID: 35690758
Krishna S, Kremsner PG. Need for optimized dosages in the design of comparative clinical trials of anti-malarial drugs. Malar J. 2022 Jun. PMID: 35725411
Moore CM, Wang J, Lin Q, Ferreira P, Avery MA, Elokely K, Staines HM, Krishna S. Selective Inhibition of Plasmodium falciparum ATPase 6 by Artemisinins and Identification of New Classes of Inhibitors after Expression in Yeast. Antimicrob Agents Chemother. 2022 Apr 25. PMID: 35465707
Kay GA, Owen SI, Giorgi E, Clark DJ, Williams CT, Menzies S, Cuevas LE, Davies BMO, Eckersley NM, Hughes GL, Kirwan DE, Krishna S, Patterson EI, Planche T, Staines HM, Adams ER. SARS-CoV-2 enzyme-linked immunosorbent assays as proxies for plaque reduction neutralisation tests. Sci Rep. 2022 Mar 1: PMID: 35233014
Kalkman LC, Hänscheid T, Krishna S, Grobusch MP. Fluid therapy for severe malaria. Lancet Infect Dis. 2022 Jan. PMID: 35051406
Balasundaram N, Ganesan S, Chendamarai E, Palani HK, Venkatraman A, Alex AA, David S, Palanikumar S, Radhakrishnan NR, M MY, Krishna S, Korula A, Kulkarni U, Janet NB, Balasubramanian P, Mathews V. Metabolic adaptation drives arsenic trioxide resistance in acute promyelocytic leukemia. Blood Adv. 2021 Oct. https://doi.org/10.1182/bloodadvances.2021005300
Thirumalaisamy V, Pallerla S R, Rüter J, Augustin Y, Kremsner P G , Krishna S, Meyer C G Host genetic factors determining COVID-19 susceptibility and severity. BioMedicine. 2021 Oct. PMID: 34655949
Savage H R, Santos V S, Edwards T, Giorgi E, Krishna S, Planche T D, Staines H M, Fitchett J R. A, Kirwan D E, Cubas Atienzar A I, Clark D J, Adams E R, Cuevas L E, Prevalence of neutralising antibodies against SARS-CoV-2 in acute infection and convalescence: A systematic review and meta-analysis. PLoS Negl Trop Dis, 2021 July. https://doi.org/10.1371/journal.pntd.0009551
Anton-Vazquez V, Hine P, Krishna S, Chaplin M, Planche T. Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection. Database Syst Rev. 2021 May. PMID: 34097767
Pernaute-Lau L, Adegnika AA, Zhou Y, Zinsou JF, Gil JP, Krishna S, Kremsner PG, Lauschke VM, Velavan TP. Pharmacogene sequencing of a Gabonese population with severe Plasmodium falciparum malaria reveals multiple novel variants with putative relevance for antimalarial treatment. Antimicrob Agents Chemother. 2021 Apr. PMID: 33875422
Gabor JJ, Kreidenweiss A, Weber S, Salama M, Sulyok M, Sulyok Z, Koehne E, Esen M, Kreuels B, Shamsrizi P, Biecker E, Mordmüller B, Berg CP, Fusco S, Köhler C, Kubicka S, Leitlein J, Addo M, Ramharter M, Schwab M, Bissinger AL, Velavan TP, Krishna S, Kremsner PG. A call to caution when hydroxychloroquine is given to elderly patients with COVID-19. Int J Infect Dis. 2021 Apr. PMID: 33848675
Brown L, Byrne RL, Fraser A, Owen SI, Cubas-Atienzar AI, Williams CT, Kay GA, Cuevas LE, Fitchett JRA, Fletcher T, Garrod G, Kontogianni K, Krishna S, Menzies S, Planche T, Sainter C, Staines HM, Turtle L, Adams ER. Self-sampling of capillary blood for SARS-CoV-2 serology. Sci Rep. 2021 Apr. PMID: 33833246
Adams ER, Wolday D, Denkinger CM, Krishna S, de Wit TFR.J Glob Health. Scaled testing for COVID-19 needs community involvement. 2021 Mar. PMID: 33763209
Emma H Baker , Kamal Patel, Jonathan Ball, Sarah Edwards, Thomas S Harrison, Arvind Kaul , Mickey Koh, Sanjeev Krishna, Susannah Leaver, Vinodh Kumar, Daniel M Forton , Insights from compassionate use of tocilizumab for COVID-19 to inform appropriate design of randomised controlled trials, Br J Clin Pharmacol. 2021 Mar. PMID: 32656822
Zaloumis SG, Whyte JM, Tarning J, Krishna S, McCaw JM, Cao P, White MT, Dini S, Fowkes FJI, Maude RJ, Kremsner P, Dondorp A, Price RN, White NJ, Simpson JA. Development and validation of an in silico decision-tool to guide optimisation of intravenous artesunate dosing regimens for severe falciparum malaria patients. Antimicrob Agents Chemother. 2021 Mar. PMID: 33685888
Vanesa AV, Cristina S, Krishna S, Timothy P. Factors influencing antimicrobial prescription attitudes in bloodstream infections: susceptibility results and beyond. An exploratory survey. J Hosp Infect. 2021 Feb, PMID: 33581245.
Henry M Staines, Daniela E Kirwan, David J Clark, Emily R Adams, Yolanda Augustin, Rachel L Byrne, Michael Cocozza, Ana I Cubas-Atienzar, Luis E Cuevas, Martina Cusinato, Benedict M O Davies, Mark Davis, Paul Davis, Annelyse Duvoix, Nicholas M Eckersley, Daniel Forton, Alice J Fraser, Gala Garrod, Linda Hadcocks, Qinxue Hu, Michael Johnson, Grant A Kay, Kesja Klekotko, Zawditu Lewis, Derek C Macallan, Josephine Mensah-Kane, Stefanie Menzies, Irene Monahan, Catherine M Moore, Gerhard Nebe-von-Caron, Sophie I Owen, Chris Sainter, Amadou A Sall, James Schouten, Christopher T Williams, John Wilkins, Kevin Woolston, Joseph R A Fitchett, Sanjeev Krishna, Tim Planche. IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Emerg Infect Dis. 2021 Jan. PMID: 33256890
Krishna S, Augustin Y, Wang J, Xu C, Staines HM, Platteeuw H, Kamarulzaman A, Sall A, Kremsner P. Repurposing Antimalarials to Tackle the COVID-19 Pandemic. Trends Parasitol. 2021 Jan, PMID: 33541791
Velavan TP, Kieu Linh LT, Kreidenweiss A, Gabor J, Krishna S, Kremsner PG. Longitudinal Monitoring of Lactate in Hospitalized and Ambulatory COVID-19 Patients. Am J Trop Med Hyg. 2021 Jan 11. PMID: 33432902.
Ackerman H, Olola CHO, Krishna S, Roberts DJ, Kremsner PG, Newton CR, Taylor T, Valim C, Casals-Pascual C. Time-to-death is a potential confounder in observational studies of blood transfusion in severe malaria - Authors' reply. Lancet Haematol. 2021 Jan, PMID: 33357473.
Bone JN, Pickerill K, Woo Kinshella ML, Vidler M, Craik R, Poston L, Stones W, Sevene E, Temmerman M, Koech Etyang A, Roca A, Russell D, Tribe RM, von Dadelszen P, Magee LA; PRECISE Network. Pregnancy cohorts and biobanking in sub- Saharan Africa: a systematic review. BMJ Glob Health. 2020 Nov; PMID: 33243854
Staines HM, Kirwan D, , Clark DJ, Adams ER, Augustin Y, Byrne RLCocozza M, Cubas-Atienzar A-I, Cuevas LE, Cusinato M, Davies BMO, Davies M, Davies P, Duvoix A, Eckersley NM, Edwards T, Fletcher T, Fraser AJ, Garrod G, Hadcocks L, Hu Q, Kay GA, Keymer K, Klekotko K, Lewis Z, Mason J, Mensah-Kane J, Menzies S, Monahan I, Moore CM, Nebe-von-Caron G, Owen SI, Sainter C, Schouten J, Turtle L, Williams C, Wilkins J, Woolston K, Sall AA, Fitchett JRA, Krishna S, Planche T (2021). Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections. Emerging Infectious Diseases 1: 85-91 doi: 10.3201/eid2701.203074. Epub 2020 Nov 30.
Hans Ackerman, Aintzane Ayestaran, Christopher H O Olola , Muminatou Jallow, Tsiri Agbenyega, Kalifa Bojang, David J Roberts, Sanjeev Krishna, Peter G Kremsner , Charles R Newton, Terrie Taylor, Clarissa Valim , Climent Casals-Pascual. The effect of blood transfusion on outcomes among African children admitted to hospital with Plasmodium falciparum malaria: a prospective, multicentre observational study. Lancet Haematol.2020 Nov. PMID: 33091354
Yolanda Augustin, Henry Staines, Sanjeev Krishna. Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing. Pharmacol Ther 2020 Oct. PMID: 33075360
Pejoski D, de Rham C, Martinez-Murillo P, Santoro F, Auderset F, Medaglini D, Pozzi G, Vono M, Lambert PH, Huttner A, Haks MC, Ottenhoff THM, Villard J, Siegrist CA; VEBCON Consortium; VSV-EBOVAC Consortium; VSV-EBOPLUS Consortium. Erratum: Author Correction: Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. NPJ Vaccines. 2020 Oct. PMID: 33083028
Balasundaram N, Ganesan S, Chendamarai E, Palani HM, Venkatraman A, Alex AA, David S, Krishna S, Korula A, Janet NB, Balasubramanian P, Mathews V. (2020) Arsenic trioxide resistance in acute promyelocytic leukemia: more to it that PML mutations..
Woo YL, Kamarulzaman A, Augustin Y, Staines HM, Altice F, Barrett M, S Krishna. (2020) A genetic predisposition for cytokine storm in life-threatening COVID-19 infections. medRVix
Lamontagne F, Agarwal A, Rochwerg B, Siemieniuk RA, Agoritsas T, Askie L, Lytvyn L, Leo YS, Macdonald H, Zeng L, Amin W, da Silva ARA, Aryal D, Barragan FAJ, Bausch FJ, Burhan E, Calfee CS, Cecconi M, Chacko B, Chanda D, Dat VQ, De Sutter A, Du B, Freedman S, Geduld H, Gee P, Gotte M, Harley N, Hashimi M, Hunt B, Jehan F, Kabra SK, Kanda S, Kim YJ, Kissoon N, Krishna S, Kuppalli K, Kwizera A, Lado Castro-Rial M, Lisboa T, Lodha R, Mahaka I, Manai H, Mendelson M, Migliori GB, Mino G, Nsutebu E, Preller J, Pshenichnaya N, Qadir N, Relan P, Sabzwari S, Sarin R, Shankar-Hari M, Sharland M, Shen Y, Ranganathan SS, Souza JP, Stegemann M, Swanstrom R, Ugarte S, Uyeki T, Venkatapuram S, Vuyiseka D, Wijewickrama A, Tran L, Zeraatkar D, Bartoszko JJ, Ge L, Brignardello-Petersen R, Owen A, Guyatt G, Diaz J, Kawano-Dourado L, Jacobs M, Vandvik PO. A living WHO guideline on drugs for covid-19. BMJ. 2020 Sep 4;370:m3379. PMID: 32887691
Agarwal A, Rochwerg B, Lamontagne F, Siemieniuk RA, Agoritsas T, Askie L, Lytvyn L, Leo YS, Macdonald H, Zeng L, Amin W, da Silva ARA, Aryal D, Barragan FAJ, Bausch FJ, Burhan E, Calfee CS, Cecconi M, Chacko B, Chanda D, Dat VQ, De Sutter A, Du B, Freedman S, Geduld H, Gee P, Gotte M, Harley N, Hashimi M, Hunt B, Jehan F, Kabra SK, Kanda S, Kim YJ, Kissoon N, Krishna S, Kuppalli K, Kwizera A, Lado Castro-Rial M, Lisboa T, Lodha R, Mahaka I, Manai H, Mendelson M, Migliori GB, Mino G, Nsutebu E, Preller J, Pshenichnaya N, Qadir N, Relan P, Sabzwari S, Sarin R, Shankar-Hari M, Sharland M, Shen Y, Ranganathan SS, Souza JP, Stegemann M, Swanstrom R, Ugarte S, Uyeki T, Venkatapuram S, Vuyiseka D, Wijewickrama A, Tran L, Zeraatkar D, Bartoszko JJ, Ge L, Brignardello-Petersen R, Owen A, Guyatt G, Diaz J, Kawano-Dourado L, Jacobs M, Vandvik PO. A living WHO guideline for drugs for COVID-19. British Medical Journal 2020 Sep 4;370:m3379. doi: 10.1136/bmj.m3379
Adams ER, Augustin Y, Byrne RL, Clark DJ, Cocozza M, Cubas-Atienzar A-I, Cuevas LE, Cusinato M, Davies BMO, Davies M, Davies P, Duvoix A, Eckersley NM, Edwards T, Fletcher T, Fraser AJ, Garrod G, Hadcocks L, Hu Q, Kay GA, Keymer K, Kirwan D, Klekotko K, Lewis Z, Mason J, Mensah-Kane J, Menzies S, Monahan I, Moore CM, Nebe-von-Caron G, Owen SI, Planche T, Sainter C, Schouten J, Staines HM, Turtle L, Williams C, Wilkins J, Woolston K, Sall AA, Fitchett JRA, Krishna S. (2020) Rapid development of COVID-19 rapid diagnostics for low resource settings: accelerating delivery through transparency, responsiveness, and open collaboration. medRVix
Baker EH, Patel K, Ball J, Edwards S, Harrison TS, Kaul A, Koh M, Krishna S, Leaver S, Kumar V, Forton DM. (2020) Insights from compassionate use of tocilizumab for COVID-19 to inform appropriate design of randomised controlled trials. British Journal of Clinical Pharmacology (in press).
Craik R, Russell D, Tribe RM, Poston L, Omuse G, Okiro P, Chege D, Diatta M, Sesay AK, Cuamba I, Carrilho C, Sevene E, Flint-O'Kane M, von Dadelszen P; PRECISE Network. PRECISE pregnancy cohort: challenges and strategies in setting up a biorepository in sub-Saharan Africa Reprod Health.2020 Apr. PMID: 32354368
Pejoski D, de Rham C, Martinez-Murillo P, Santoro F, Auderset F, Medaglini D, Pozzi G, Vono M, Lambert PH, Huttner A, Haks MC, Ottenhoff THM, Villard J, Siegrist CA; VEBCON Consortium; VSV-EBOVAC Consortium; VSV-EBOPLUS Consortium. Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. NPJ Vaccines. 2020 Apr. PMID: 33580050
Magee LA, Strang A, Li L, Tu D, Tumtaweetikul W, Craik R, Daniele M, Etyang AK, D'Alessandro U, Ogochukwu O, Roca A, Sevene E, Chin P, Tchavana C, Temmerman M, von Dadelszen P; PRECISE Network. The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) database: open-access data collection in maternal and newborn health. Reprod Health. 2020 Apr. PMID: 32354365
Daniele MAS, Martinez-Alvarez M, Etyang AK, Vidler M, Salisbury T, Makanga PT, Musitia P, Flint-O'Kane M, Brown TW, Diallo BA, Boene H, Stones W, von Dadelszen P, Magee LA, Sandall J; PRECISE Network. The contribution of qualitative research within the PRECISE study in sub-Saharan Africa. Reprod Health. 2020 Apr. PMID: 32354359
Flint-O'Kane M, von Dadelszen P, Makanga PT, Sevene E, Roca A, Dukes P, Hinrichs-Krapels S, Craik R, Magee LA, Temmerman M; PRECISE Network. Harnessing the PRECISE network as a platform to strengthen global capacity for maternal and child health research in sub-Saharan Africa. Reprod Health. 2020 Apr. PMID: 32354358
von Dadelszen P, Flint-O'Kane M, Poston L, Craik R, Russell D, Tribe RM, d'Alessandro U, Roca A, Jah H, Temmerman M, Koech Etyang A, Sevene E, Chin P, Lawn JE, Blencowe H, Sandall J, Salisbury TT, Barratt B, Shennan AH, Makanga PT, Magee LA; PRECISE Network. The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network's first protocol: deep phenotyping in three sub-Saharan African countries. Reprod Health. 2020 Apr .PMID: 32354357
Pejoski D, de Rham C, Martinez-Murillo P, Santoro F, Auderset F, Medaglini D, Pozzi G, Vono M, Lambert PH, Huttner A, Haks MC, Ottenhoff THM, Villard J, Siegrist CA; VEBCON Consortium; VSV-EBOVAC Consortium; VSV-EBOPLUS Consortium. Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. NPJ Vaccines. 2020 Apr. eCollection 2020. PMID: 32337075
Jigang Wang, Chengchao Xu, Yin Kwan Wong, Yingke He, Ayôla A Adegnika, Peter G Kremsner, Selidji T Agnandji, Amadou A Sall, Zhen Liang, Chen Qiu, Fu Long Liao, Tingliang Jiang, Sanjeev Krishna, Youyou Tu. Preparedness is essential for malaria-endemic regions during the COVID-19 pandemic. Lancet. 2020 Mar. PMID: 32192582
Clark DJ, Moore CM, Flanagan M, Bocxlaer KV, Piperaki ET, Yardley V, Croft SL, Tyson J, Whitehouse SP, O'Halloran J, Krishna S, Staines HM.An efficient and novel technology for the extraction of parasite genomic DNA from whole blood or culture. Biotechniques. 2019 Nov. PMID: 31774301
Wang J, Xu C, Liao FL, Jiang T, Krishna S, Tu Y. Suboptimal dosing triggers artemisinin partner drug resistance. Lancet Infect Dis. 2019 Nov. PMID:31657775
Krishna S. Triple artemisinin-containing combination anti-malarial treatments should be implemented now to delay the emergence of resistance: the case against. Malar J. 2019 Oct. PMID: 31581951
Wang J, Krishna S, Xu C. A Temporizing Solution to "Artemisinin Resistance". Reply. N Engl J Med. 2019 Sep PMID: 31483980
Wang J, Xu C, Liao FL, Jiang T, Krishna S, Tu Y. A Temporizing Solution to "Artemisinin Resistance". N Engl J Med. 2019 May PMID: 31018065
Wallbank BA, Dominicus CS, Broncel M, Legrave N, Kelly G, MacRae JI, Staines HM, Treeck M. Characterisation of the Toxoplasma gondii tyrosine transporter and its phosphorylation by the calcium-dependent protein kinase 3. Mol Microbiol. 2019 May PMID: 30402958
Poetsch JH, Dahlke C, Zinser ME, Kasonta R, Lunemann S, Rechtien A, Ly ML, Stubbe HC, Krähling V, Biedenkopf N, Eickmann M, Fehling SK, Olearo F, Strecker T, Sharma P, Lang KS, Lohse AW, Schmiedel S, Becker S; VSV-Ebola Consortium (VEBCON) , Addo MM. Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans. J Infect Dis. Jan 2019, PMID: 30452666
Nsanzabana C, Ariey F, Beck HP, Ding XC, Kamau E, Krishna S, Legrand E, Lucchi N, Miotto O, Nag S, Noedl H, Roper C, Rosenthal PJ, Schallig HDFH, Taylor SM, Volkman SK, Gonzalez IJ. Molecular assays for antimalarial drug resistance surveillance: A target product profile.PLoS One. 2018 Sep., eCollection 2018. PMID: 30235327
Lee AH, Dhingra SK, Lewis IA, Singh MK, Siriwardana A, Dalal S, Rubiano K, Klein MS, Baska KS, Krishna S, Klemba M, Roepe PD, Llinás M, Garcia CRS, Fidock DA. Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter. Sci Rep. 2018 Sep. PMID: 30206341
Huttner A, Agnandji ST, Combescure C, Fernandes JF, Bache EB, Kabwende L, Ndungu FM, Brosnahan J, Monath TP, Lemaître B, Grillet S, Botto M, Engler O, Portmann J, Siegrist D, Bejon P, Silvera P, Kremsner P, Siegrist CA; VEBCON; VSV-EBOVAC; VSV-EBOPLUS Consortia. Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study. Lancet. Jul. 2018. PMID: 29627147
Clark DJ, Tyson J, Sails AD, Krishna S, Staines HM. The current landscape of nucleic acid tests for filovirus detection. J Clin Virol. Jun. 2018, PMID: 29625392
Bassat Q, Krishna S. Widening the options for recurrent malaria.Lancet. Apr. 2018. PMID: 29606365
Staines HM, Burrow R, Teo BH, Chis Ster I, Kremsner PG, Krishna S. Clinical implications of Plasmodium resistance to atovaquone/proguanil: a systematic review and meta-analysis. J Antimicrob Chemother. 2017 Dec 11, PMID: 29237012
Agnandji ST, Fernandes JF, Bache EB, Obiang Mba RM, Brosnahan JS, Kabwende L, Pitzinger P, Staarink P, Massinga-Loembe M, Krähling V, Biedenkopf N, Fehling SK, Strecker T, Clark DJ, Staines HM, Hooper JW, Silvera P, Moorthy V, Kieny MP, Adegnika AA, Grobusch MP, Becker S, Ramharter M, Mordmüller B, Lell B; VEBCON Consortium, Krishna S, Kremsner PG. Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial. PLoS Med. 2017 Oct., PMID: 28985239
Rechtien A, Richert L, Lorenzo H, Martrus G, Hejblum B, Dahlke C, Kasonta R, Zinser M, Stubbe H, Matschl U, Lohse A, Krähling V, Eickmann M, Becker S; VEBCON Consortium, Thiébaut R, Altfeld M, Addo MM. Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV. Cell Rep. 2017 Aug., PMID: 28854372
Wang J, Zhang J, Shi Y, Xu C, Zhang C, Wong YK, Lee YM, Krishna S, He Y, Lim TK, Sim W, Hua ZC, Shen HM, Lin Q.Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity. ACS Cent Sci. 2017 Jul 26 Epub 2017 Jun 28. PMID: 28776016
Meireles P, Mendes AM, Aroeira RI, Mounce BC, Vignuzzi M, Staines HM, Prudêncio M. Uptake and metabolism of arginine impact Plasmodium development in the liver. Sci Rep. 2017 Jun PMID: 28642498 Efferth T, Schöttler U, Krishna S, Schmiedek P, Wenz F, Giordano FA. Answer to the comment of Hai Lu et al. regarding "Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report and review of the literature. Arch Toxicol (2016)". Arch Toxicol. 2017 Jun; PMID: 28317071
Nguetse CN, Adegnika AA, Agbenyega T, Ogutu BR, Krishna S, Kremsner PG, Velavan TP. Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria. Malar J. 2017 May PMID: 28535801
Gil JP, Krishna S. Pfmdr1 (Plasmodium falciparum multidrug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies. (2017) Expert Review in Anti Infective Therapies. Apr 10:1-17. PMID: 28355493
Dahlke C, Kasonta R, Lunemann S, Krähling V, Zinser ME, Biedenkopf N, Fehling SK, Ly ML, Rechtien A, Stubbe HC, Olearo F, Borregaard S, Jambrecina A, Stahl F, Strecker T, Eickmann M, Lütgehetmann M, Spohn M, Schmiedel S, Lohse AW, Becker S, Addo MM; VEBCON Consortium. Dose-dependent T cell dynamics and cytokine cascade following rVSV-ZEBOV immunization. EBioMedicine. 2017 Apr 5. pii: S2352-3964(17)30141-X PMID: 28434944
Huttner A, Combescure C, Grillet S, Haks MC, Quinten E, Modoux C, Agnandji ST, Brosnahan J, Dayer JA, Harandi AM, Kaiser L, Medaglini D, Monath T; VEBCON and VSV-EBOVAC Consortia., Roux-Lombard P, Kremsner PG, Ottenhoff TH, Siegrist CA. (2017). A dose-dependent plasma signature of the safety and immunogenicity of the rVSV-Ebola vaccine in Europe and Africa. Sci Transl Med. 2017 Apr 12;9(385). PMID: 28404856
Efferth T, Schöttler U, Krishna S, Schmiedek P, Wenz F, Giordano FA. Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature.Arch Toxicol. 2017 Apr PMID: 27519711
Meireles P, Sales-Dias J, Andrade CM, Mello-Vieira J, Mancio-Silva L, Simas JP, Staines HM, Prudêncio M. GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection. Cell Microbiol. 2017 Feb. PMID: 27404888
Macciocchi D, Lanini S, Vairo F, Zumla A, Figueiredo LT, Lauria FN, Strada G, Brouqui P, Puro V, Krishna S, Kremsner P, Scognamiglio P, Köhler C, Nicastri E, Di Caro A, Cieri RM, Ioannidis JP, Kobinger G, Burattini MN, Ippolito G. Short-term economic impact of the Zika virus outbreak.New Microbiol. 2016 Oct. PMID: 28004846
Krishna S, Staines HM, Kremsner PG. Artemisinin Resistance and Blame Game. Clin Infect Dis. 2016 Oct. No abstract available. PMID:27461919
Arch Toxicol. 2016 Aug 12 Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature. PMID:27519711
Meireles P, Sales-Dias J, Andrade CM, Mello-Vieira J, Mancio-Silva L, Simas JP, Staines HM, Prudêncio M. GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection. Cell Microbiol. 2016 Jul 12. PMID: 27404888
Krishna S, Staines HM, Kremsner PG. Clin Infect Dis. 2016 Jul Artemisinin Resistance and the Blame Game. PMID:27461919
Wu Y, Wu RW, Cheu KW, Williams ID, Krishna S, Slavic K, Gravett AM, Liu WM, Wong HN, Haynes RK. ChemMedChem. 2016 Jul Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins. PMID: 27273875
Karuppuchamy T, Behrens EH, González-Cabrera P, Sarkisyan G, Gima L, Boyer JD, Bamias G, Jedlicka P, Veny M, Clark D, Peach R, Scott F, Rosen H, Rivera-Nieves J, Mucosal Immunol. 2016 Apr 6. Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease. PMID: 27049060
Schmutzhard J, Lackner P, Helbok R, Hurth HV, Aregger FC, Muigg V, Kegele J, Bunk S, Oberhammer L, Fischer N, Pinggera L, Otieno A, Ogutu B, Agbenyega T, Ansong D, Adegnika AA, Issifou S, Zorowka P, Krishna S, Mordmüller B, Schmutzhard E, Kremsner P. BMC Med. 2016 Apr Erratum to: Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study. PMID: 27106862
Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA. N Engl J Med. 2016 Apr. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe. PMID: 25830326
Ippolito G, Lanini S, Brouqui P, Di Caro A, Vairo F, Fusco FM, Krishna S, Capobianchi MR, Kyobe-Bosa H, Puro V, Wölfel R, Avsic-Zupanc T, Ioannidis JP, Portella G, Kremsner P, Dar O, Bates M, Zumla A. Lancet Infect Dis. 2016 Apr Non-randomised Ebola trials--lessons for optimal outbreak research. PMID: 27036341
Saeed ME, Krishna S, Greten HJ, Kremsner PG, Efferth T. Pharmacol Res. 2016 Aug. Antischistosomal activity of artemisinin derivatives in vivo and in patients. PMID: 26902577
Slavic K, Krishna S, Lahree A, Bouyer G, Hanson KK, Vera I, Pittman JK, Staines HM, Mota MM. Nat Commun. 2016 Jan. A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium. PMID:26786069
Kremsner PG, Adegnika AA, Hounkpatin AB, Zinsou JF, Taylor TE, Chimalizeni Y, Liomba A, Kombila M, Bouyou-Akotet MK, Mawili Mboumba DP, Agbenyega T, Ansong D, Sylverken J, Ogutu BR, Otieno GA, Wangwe A, Bojang KA, Okomo U, Sanya-Isijola F, Newton CR, Njuguna P, Kazungu M, Kerb R, Geditz M, Schwab M, Velavan TP, Nguetse C, Köhler C, Issifou S, Bolte S, Engleitner T, Mordmüller B, Krishna S. PLoS Med. 2016 Jan. Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial. PMID:26757276
Augustin Y, Krishna S, Kumar D, Pantziarka P. Ecancermedicalscience. 2015 Oct. The wisdom of crowds and the repurposing of artesunate as an anticancer drug. PMID:26557887
Pulcini S, Staines HM, Lee AH, Shafik SH, Bouyer G, Moore CM, Daley DA, Hoke MJ, Altenhofen LM, Painter HJ, Mu J, Ferguson DJ, Llinás M, Martin RE, Fidock DA, Cooper RA, Krishna S. Sci Rep. 2015 Sep. Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities. PMID:26420308
Ippolito G, Lanini S, Brouqui P, Di Caro A, Vairo F, Abdulla S, Fusco FM, Krishna S, Capobianchi MR, Kyobe-Bosa H, Lewis DJ, Puro V, Wolfel R, Avsic-Zupanc T, Dar O, Mwaba P, Bates M, Heymann D, Zumla A. Lancet Infect Dis. 2015 Jul. Ebola: missed opportunities for Europe-Africa research. PMID: 26231479
Schmutzhard J, Lackner P, Helbok R, Hurth HV, Aregger FC, Muigg V, Kegele J, Bunk S, Oberhammer L, Fischer N, Pinggera L, Otieno A, Ogutu B, Agbenyega T, Ansong D, Adegnika AA, Issifou S, Zorowka P, Krishna S, Mordmüller B, Schmutzhard E, Kremsner P. BMC Med. 2015 May. Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions--a prospective multicenter cohort study. PMID:26021376
Lanini S, Zumla A, Ioannidis JP, Caro AD, Krishna S, Gostin L, Girardi E, Pletschette M, Strada G, Baritussio A, Portella G, Apolone G, Cavuto S, Satolli R, Kremsner P, Vairo F, Ippolito G. Lancet Infect Dis. 2015 Apr 13. Are adaptive randomised trials or non-randomised studies the best way to address the Ebola outbreak in west Africa? PMID: 25881871
Agnandji ST1, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe - Preliminary Report. N Engl J Med. 2015 Apr 1. PMID: 25830326
Pinheiro MM, Ahmed MA, Millar SB, Sanderson T, Otto TD, Lu WC, Krishna S, Rayner JC, Cox-Singh J. Plasmodium knowlesi Genome Sequences from Clinical Isolates Reveal Extensive Genomic Dimorphism. PLoS One. 2015 Apr 1, PMID: 25830531
Rolling T, Agbenyega T, Krishna S, Kremsner PG, Cramer JP. Delayed haemolysis after artesunate treatment of severe malaria - Review of the literature and perspective. Travel Med Infect Dis. 2015 Mar-Apr; PMID: 25812775
The WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group. (2015). The Effect of Dosing Strategies on the Therapeutic Efficacy of Artesunate Amodiaquine for Uncomplicated Malaria: A Meta-Analysis of Individual Patient Data. BMC Medicine. PMID: 25888957
This must be the year we beat Ebola in West Africa .Sanjeev Krishna receives funding from the World Health Organisation and the Wellcome Trust as part of a consortium to develop a vaccine against Ebola. Carwyn Hooper does not work for, consult to, own shares in or receive funding from any company or organisation that would benefit from this article, and has no relevant affiliations. Published by The Converstation 2 January, 2015
Sanjeev Krishna, Senthil Ganapathi, Irina Chis Ster, Mohamed E.M. Saeed, Matt Cowan, Caroline Finlayson, Hajnalka Kovacsevics, Herwig Jansen, Peter G. Kremsner, Thomas Efferth, Devinder Kumar. A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer. EBioMedicine, EBIOM-00033; No of Pages 9, 2014 PMID: 26137537
Zaloumis S, Tarning J, Krishna S, Price R, White NJ, DavisTME, McCaw J, Olliaro P, Maude R, Kremsner P, Dondorp A, Gomes M, Barnes K, and Simpson J. (2014). Population pharmacokinetics of intravenous artesunate: a pooled analysis of individual data from patients with severe malaria. Clinical Pharmacology and Therapeutics: Pharmacometrics and Systems Pharmacology. (in press).
Ahmed AM, Pinheiro MM, Divis, PC, Sinner A, Zainudin R, Wong IT Lu CW, Singh-Khaira S, Millar SB, Lynch S, Willmann M, Singh B, Krishna S, Cox-Singh J. (2014). Disease progression in Plasmodium knowlesi is linked to variation in invasion gene family members. PLoS Neglected Diseases 8:e3086 PMID: 25121807
To fight malaria, we now have genetic weapons that track and kill. Every year malaria kills more than 600,000, which is a little less than the population of Bhutan. There are some simple solutions to control the disease, but keeping the numbers of mosquitoes with malarial parasites down remains a challenge. Published by The Converstation 16th June 2014.
Talman A, Prieto JH, Marques S, Ubaida-Mohien C, Lawniczak M, Wass MN< Xu T, Frank R, Ecker A, Stanway RS, Krishna S, Sternberg MJE, Christophides GK, Graham DR, Dinglasan RR, Yates III JR, Sinden RE. (2014). Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility. Malaria Journal PMID: 25124718
Foster D, Cox-Singh J, Mohamad DS, Krishna S, Chin PP, Singh B. Evaluation of three rapid diagnostic tests for the detection of human infections with Plasmodium knowles. Malar J. 2014 Feb 18;13(1):60. PMID: 24548805
Rolling T, Agbenyega T, Issifou S, Adegnika AA, Sylverken J, Spahlinger D, Ansong D, Löhr SJ, Burchard GD, May J, Mordmüller B, Krishna S, Kremsner PG,Cramer JP. Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria--A Double-center Prospective Study. J Infect Dis. 2014 Jan 29. PMID: 24376273
Krishna S, Pulcini S, Moore CM, Teo BH, Staines HM. Trends Pharmacol Sci. 2014 Jan;35(1):4-11. Pumped up: reflections on PfATP6 as the target for artemisinins. PMID: 24268763
Krishna, S., & Kremsner, P. G. (2013). Artemisinin resistance needs to be defined rigorously to be understood: response to Dondorp and Ringwald.. Trends Parasitol. 2013 Aug;29(8):361-2. PMID: 23809865
Ratzinger F1, Bruckschwaiger H, Wischenbart M, Parschalk B, Fernandez-Reyes D, Lagler H, Indra A, Graninger W, Winkler S, Krishna S, Ramharter M. (2012). Rapid Diagnostic Algorithms as a Screening Tool for Tuberculosis: An Assessor Blinded Cross-Sectional Study. PLoS One. 2012;7(11):e496586 pages. PMID: 23185397
Tiberti N, Matovu E, Hainard A, Enyaru JC, Lejon V, Robin X, Turck N, Ngoyi DM, Krishna S, Bisser S, Courtioux B, Büscher P, Kristensson K, Ndung’u JM, Sanchez J-C. (2013). New Biomarkers for stage determination in Trypanosoma brucei rhodesiense sleeping sickness patients. Clinical and Translational Medicine PMID: 23369533
Pulcini S, Staines HM, Pitman JK, Slavic K, Doerig C, Halbert J, Tewari R, Shah F, Avery MA, Haynes RK, Krishna S (2013). Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes. Journal of Infectious Diseases PMID: 23599312
Newton PN, Stepniewska K, Dondorp A, Silamut K, Chierakul W, Krishna S, Davies TME, Suputtamongkol Y, Angus B, Pukrittayakamee S, Ruangveerayuth R, Hanson J, White NJ, Day NPJ. (2013). Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand. Malaria J PMID: 23829311
Tjhin ET, Staines HM, van Schalkwyk DA, Krishna S, Saliba KJ. (2013). Studies with Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis. FEBS Letters PMID: 23954294 Krishna S, Kremsner PG. (2013). Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy. Trends in Parasitology PMID: 23623760
Controlling mosquito sex lives is one way to filght malaria. Controlling malaria is a war being waged on many fronts. Mosquito nets and coils repel mosquitoes from their human feast…Published by The Converstation 29th October 2013
New malaria vaccine has its flaws, but it's better that nothing. The announcement that GlaxoSmithKline (GSK) aims to register a malaria vaccine came on the same day Peter Higgs and Francois Englert were awarded the Nobel prize in physics for predicting the existence…Published by The Converstation 9th October 2013
Fatih FA, Staines HM, Siner A, Ahmed MA, Woon LC, Pasini EM, Kocken CH, Singh B, Cox-Singh J, Krishna S. (2013). Susceptibility of human Plasmodium knowlesi infections to antimalarials. Malaria Journal PMID: 24245918
Krishna S, Pulcini S, Moore CM, Teo BH, Staines HM. (2013). Pumped up: reflections on PfATP6 as the target for artemisinins. Trends in Pharmacological Sciences PMID: 24268763
Rolling T, Agbenyega T, Issifou S, Adegnika AA, Sylverken J, Spahlinger D, Ansong D, Löhr SJ, Burchard GD, May J, Mordmüller B, Krishna S, Kremsner PG, Cramer JP. (2013). Delayed hemolysis after treatment with parenteral artesunate in African children with severe malaria--a double-center prospective study.Journal of Infectious Diseases PMID: 24376273
Fatih FA, Siner A, Ahmed A, Woon LC, Craig A, Singh B, Krishna S, Cox-Singh J. (2012). Cytoadherence and virulence – the case of Plasmodium knowlesi malaria. Malaria Journal 11:33. PMID: 22305466
Craig A, Grau GE, Kazura JW, Milner D, Barnwell JW, Turner G and Langhorne J on behalf of 22 participants (listed in Table 1) of the Hinxton Retreat meeting on “Animal Models for Research on Severe Malaria”. (2012). PLoS Pathogens 8: e1002401. PMID: 22319438
Ratzinger F, Bruckschwaiger H, Wischenbart M, Parschalk B, Fernandez-Reyes D, Indra A, Graninger W, Winkler S, Krishna S, Ramharter M. (2012). Rapid diagnostic algorithms as a screening tool for tuberculosis: an assessor blinded cross-sectional study. PLoS One 2012;7(11):e49658. Epub 2012 Nov 21 PMID: 23185397
Pillai D, Lau R, Khairnar K, Lepore R, Via A, Staines HM, Krishna S. (2012). Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum. Malaria Journal Apr 27;11:131. PMID: 22540925
Guttery DS, Pittman JK, Frénal K, Poulin B, McFarlane LR, Slavic K, Wheatley S, Soldati-Favre D, Krishna S, Tewari R, Staines HM. (2013). The Plasmodium berghei Ca2+/H+ exchanger, PbCAX, is essential for environmental tolerance to Ca2+ during sexual development. PLoS Pathogen PMID: 23468629
Tiberti N, Hainard A, Lejon V, Courtioux B, Matovu E, Enyaru JC, Robin X, Turck N, Kristensson K, Ngoyi DM, Vatunga GM, Krishna S, Büscher P, Bisser S, Ndung’u JM, Sanchez J-C. (2012). Cerebrospinal fluid neopterin as a marker of the meningo-encephalitic stage of Trypanosoma brucei gambiense sleeping sickness PLoS One 2012;7(7):e40909. Epub 2012 Jul 18. PMID: 22815865
Willmann M, Ahmed A, Siner A, Tien WI, Voon LC, Singh B, Krishna S, Cox-Singh J. (2012). Laboratory markers of disease severity in Plasmodium knowlesi infection Malaria J. PMID: 23110615
Krishna, S. (2012). Adjunctive management of malaria.. Curr Opin Infect Dis, 25(5), 484-488. PMID: 22907277
Pillai D, Lau R, Khairnar K, Lepore R, Via A, Staines HM, Krishna S. (2012). Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum. Malaria Journal Apr 27;11:131. PMID: 22540925
Kremsner PG, Taylor T, Issifou S, Kombila M, Chimalizeni Y, Kawaza K, Akotet KB, Duscha M, Mordmüller B, Kösters K, Humberg A, Miller RS, Weina P, Duparc S, Möhrle J, Kun JFJ, Planche T, Teja-Isavadharm P, Simpson JA, Köhler C, Krishna S. (2012). A simplified intravenous artesunate regimen for severe malaria. Journal of Infectious Diseases 205: 312-319. PMID: 22180622
Krishna, S., & Staines, H. M. (2012). Non-Antifolate Antibiotics: Clindamycin,Doxycycline, Azithromycin and Fosmidomycin.
H. M. Staines, & S. Krishna (Eds.), Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use (pp. 141-156). Basel: Springer. 315 pages (16 chapters) ISBN 978-3-0346-0479-6.
Pooley S, Fatih F, Krishna S, Gerisch M, Haynes RK, Wong H-N, Staines HM. (2011). Artemisone uptake in Plasmodium falciparum-infected erythrocytes. Antimicrobial Agents and Chemotherapy 55: 550-6 PMID: 21135191
Lubell Y, Staedke S, Greenwood BM, Kamya M, Newton P, Molyneux M, Reyburn H, Snow R, D’Allesandro U, English M, Day N, Kremsner PG, Dondorp A, Mbacham W, Dorsey G, Owusu-Agyei S, Maitland K, Krishna S, Newton C, Pasvol G, von Seidlein L, Taylor T, White NJ, Binka F, Mills A, Whitty CJM. (2011). Likely health outcomes for untreated febrile illness in the tropics in decision and economic models; a Delphi survey PLoS One 6: e17439.PMID: 21390277
Slavic K, Talman AM, Delves MJ, Prudêncio M, Straschil U, Derbyshire ET, Xu Z, Sinden RE, Mota MM, Morin C, Tewari R, Krishna S, Staines HM. (2011). Use of a selective inhibitor to define the physiological importance of the plasmodial hexose transporter in the different stages of the parasite’s life cycle. Antimicrobial Agents and Chemotherapy 55: 2824-2830. PMID: 21402842
Slavic K, Derbyshire E, Staines HM, Krishna S. (2011). Hexose transporters as novel targets for antiparasitic drug discovery. Malaria Journal 10: 165.PMID: 21676209
Salcedo-Sora JE, Ochung E, Nzila A, Beveridge S, Biagini GA, Stocks PA, Johnson D, O’Neill PM, Krishna S, Ward SA, Bray PG. (2011). The molecular basis of folate salvage in Plasmodium falciparum: characterisation of two folate transporters. Journal of Biological Chemistry 286: 44659 – 44668.PMID: 21998306
Cox-Singh J. Singh B, Daneshvar C, Planche T, Parker-Williams J, Krishna S. (2011). Antiinflammatory markers predominate in acute human Plasmodium knowlesi malaria. PLoS One 6:e20541. PMID: 21687657
Kremsner PG, Taylor T, Issifou S, Kombila M, Chimalizeni Y, Kawaza K, Akotet KB, Duscha M, Mordmüller B, Kösters K, Humberg A, Miller RS, Weina P, Duparc S, Möhrle J, Kun JFJ, Planche T, Teja-Isavadharm P, Simpson JA, Köhler C, Krishna S. (2011). A simplified intravenous artesunate regimen for severe malaria. Journal of Infectious Diseases 205: 312-319. PMID: 22180622
Cox-Singh J, Hiu J, Lucas S, Divis PC, Zulkarnaen AN, Wang PC, Adem P, Zaki SR, Singh B, Krishna S. (2010). Severe malaria: A case of fatal Plasmodium knowlesi infection with post mortem findings – a case report. Malaria Journal 9: 10. PMID: 20064229
Staines H, Derbyshire ET, Slavic K, Tattersall A, Vial V, Krishna S. (2010). Exploiting the therapeutic potential of transporters of Plasmodium falciparum. Trends in Parasitology 26: 284-96. PMID: 20392668
K, Straschil U, Reininger L, Doerig C, Morin C, Tewari R, Krishna S. (2010). Life cycle studies of the hexose transporter of Plasmodium species. Molecular Microbiology 75: 1402-1413. PMID: 20132450
A, Pope C, Bray S, Riley P, Breathnach A, Krishna S, Planche T. (2010). Prospective assessment of two-stage testing for Clostridium difficile. Journal of Hospital Infection 76: 18-22. PMID: 20638749
Krishna S, Pulcini S, Fatih F, Staines H. (2010). Artemisinins and the biological basis of the PfATP6/SERCA hypothesis. Trends in Parasitology 26: 517-523. PMID: 20638904
Cowan M, Rahman T, Krishna S. (2010). Proteomic approaches in the search for biomarkers of liver fibrosis. Trends in Molecular Medicine 16: 171-183. PMID: 20304704
Gravett AM, Liu WM, Krishna S, Chan W-C, Haynes RK, Wilson N, Dalgleish AG. (2010). In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents. Cancer Chemotherapy and Pharmacology 67: 569-577. PMID: 20490800
Cardi D, Pozza A, Arnou B, Marchal E, Clausen JD, Andersen JP, Krishna S, Møller JV, le Maire M, Jaxel C. (2010). Purified E255L mutant Serca1a and purified PfATP6 are sensitive to SERCA-type inhibitors but insensitive to artemisinins. Journal of Biological Chemistry 285: 26406-16. PMID: 20530490
Valderramos SG, Scanfield D, Uhlemann A-C, Fidock DA, Krishna S. (2010). Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrobial Agents and Chemotherapy 54: 3842 – 52. PMID: 20566762
Planche T,Macallan DC, Sobande T, Borrmann S, Kun JF, Krishna S, Kremsner PG. (2010). Nitric oxide generation in children with malaria and the NOS2G-954C promotor polymorphism. American Journal of Physiology, Regulatory, Integrative and Compatative Physiology 299: R1248-53. PMID: 20811009
Kremsner PG, Valim C, Missinou M, Olola C, Krishna S, Issifou S, Kombila M, Bwanaisa L, Mithwanin S, Newton C, Agbenyega T, Pinder M, Bojang K, Wypij D, Taylor T. (2009). The prognostic value of circulating pigmented cells in severe malaria in African children. Journal of Infectious Diseases 199 142-150. PMID: 19086817
Gomes MF, Faiz MA, Gyapong J, Warasme M, Agbenyega T, Babiker A, Baiden F, Bin Yunus E, Binka F, Ckerk C, Folb P, Hassan R, Hossein Md A, Kimbute O, Kitua A, Krishna S, Makasi C, Mensah N, Mrango Z, Olliaro P, Peto R, Peto TJ, Rahman MR, Ribiero I, Samad R, White NJ for the Study 13 research group. (2009). Pre-referral rectal artesunate to prevent death and disability in severe malaria: placebo-controlled trial. The Lancet 373: 557-566. PMID: 19059639
Macallan DC, Abaye DA, Dottin S, Onanga M, Kombila M, Dzeing-Ella A, Kremsner PG, Krishna S, Planche T. (2009). Blood volume and red cell mass in children with moderate and severe malaria measured by chromium-53 dilution and gas chromatography/mass spectrometric analysis. Rapid Communications in Mass Spectrometry 23: 2467-75. PMID: 19603467
Prudêncio M, Derbyshire ET, Marques CA, Krishna S, Mota MM, Staines HM. (2009). Plasmodium berghei infection induces volume-regulated anion channel-like activity in human hepatoma cells. Cellular Microbiology 11: 1492-501. PMID: 19496788
Slavic K, Derbyshire E, Naftalin RJ, Krishna S, Staines HM. (2009). Comparison of effects of green tea catechins on apicomplexan hexose transporters and mammalian orthologues. Molecular and Biochemical Parasitology 168: 113-116. PMID: 19577593
Doerig C, Baker D, Billker O, Blackman MJ, Chitnis C, Dhar K, Heussler V, Holder AA, Kocken C, Krishna S, Langsley G, Lasonder E, Menard R, Meissner M, Pradel G, Ranford-Cartwright L, Sharma A, Sharma P, Tardieux T, Tatu U, Alano P. (2009). Signalling in malaria parasites. The MALSIG consortium. Parasite 16: 169-182. PMID: 19839262
Toovey S, Bustamante LY, Uhlemann A-C, East M, Krishna S. (2008). Effect of artemisinins and amino alcohol partner antimalarials on mammalian sarcoendoplasmic reticulum adenosine triphosphatase (SERCA) activity. Basic and Clinical Pharmacology and Toxicology 2008 Sep;103(3):209-13. Epub 2008 Jul 18. PMID: 18684232
Derbyshire E, Franssen FJ, de Vries E, Morin C, Woodrow CJ, Krishna S, Staines HM. (2008). Identification, expression and characterisation of a Babesia bovis hexose transporter. Molecular and Biochemical Parasitology Oct;161(2):124-9. Epub 2008 Jun 27. PMID: 18638508
Rojas-Galeano S, Hseih E, Agranoff D, Krishna S, Fernandez-Reyes D. (2008). Estimation of relevant variables on high-dimensional biological patterns using iterated weighted kernal functions. PLoS One 26: 3 PMID: 18509521
Planche T, Aghaizu A, Holliman R, Polienicki J, Breathack A, Krishna S. (2008). Diagnosis of Clostridium difficile by use of toxin detection kits: a systematic review. Lancet Infectious Diseases 8: 777-84. PMID: 18977696
Krishna S, Bustamante L, Haynes RK, Staines HM. (2008). Artemisinins: their growing importance in medicine. Trends in Pharmacological Sciences 29: 520-7.PMID: 18752857