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Overview

Dr Axel Nohturfft

Senior Lecturer
Course director. Module organiser. Teacher. Researcher.
Molecular & Clinical Sciences Research Institute
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Overview

Dr Axel Nohturfft is a Senior Lecturer at St. George's University of London with a PhD in biochemistry. He teaches a variety of subjects (cell and molecular biology, bioinformatics, scientific writing) and supervises student research projects. Dr Nohturfft is the course director for the MRes/MSc Translational Medicine programme, Deputy Course Director for MSc Genomic Medicine, module organiser on Translational Medicine and MPharm, and co-lead for the BSc Biomedical Science Personal Training Year programme. His research interests revolve around the regulation of cholesterol homeostasis and organelle biogenesis.

Milano L, Charlier CF, Andreguetti R, Cox T, Healing E, Thomé MP, Elliott RM, Samson LD, Masson JY, Lenz G, Henriques JAP, Nohturfft A, Meira LB. A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2111404119. doi: 10.1073/pnas.2111404119. PMID: 35197283; PMCID: PMC8892324.

 

FitzPatrick LM, Hawkins KE, Delhove JMKM, Fernandez E, Soldati C, Bullen LF, Nohturfft A, Waddington SN, Medina DL, Bolaños JP, McKay TR. NF-κB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program. Stem Cell Reports. 2018 Jun 5;10(6):1766-1781. doi: 10.1016/j.stemcr.2018.03.015. Epub 2018 Apr 19. PMID: 29681545; PMCID: PMC5989595.

 

Giotis ES, Ross CS, Robey RC, Nohturfft A, Goodbourn S, Skinner MA. Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells. Sci Rep. 2017 Dec 13;7(1):17485. doi: 10.1038/s41598-017-17730-2. PMID: 29235573; PMCID: PMC5727488.

 

Cheng C, Ru P, Geng F, Liu J, Yoo JY, Wu X, Cheng X, Euthine V, Hu P, Guo JY, Lefai E, Kaur B, Nohturfft A, Ma J, Chakravarti A, Guo D. Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth. Cancer Cell. 2015 Nov 9;28(5):569-581. doi: 10.1016/j.ccell.2015.09.021. PMID: 26555173; PMCID: PMC4643405.

 

Charolidi N, Pirianov G, Torsney E, Pearce S, Laing K, Nohturfft A, Cockerill GW. Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm. J Vasc Res. 2015;52(2):81-93. doi: 10.1159/000430986. Epub 2015 Jun 20. PMID: 26113112; PMCID: PMC6381870.

 

Brignull LM, Czimmerer Z, Saidi H, Daniel B, Villela I, Bartlett NW, Johnston SL, Meira LB, Nagy L, Nohturfft A. Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. BMC Genomics. 2013 Dec 5;14:853. doi: 10.1186/1471-2164-14-853. PMID: 24314139; PMCID: PMC3880092.

 

Chatterjee S, Szustakowski JD, Nanguneri NR, Mickanin C, Labow MA, Nohturfft A, Dev KK, Sivasankaran R. Identification of novel genes and pathways regulating SREBP transcriptional activity. PLoS One. 2009;4(4):e5197. doi: 10.1371/journal.pone.0005197. Epub 2009 Apr 21. PMID: 19381295; PMCID: PMC2668173.

 

Zhang S, Nohturfft A. Studying Membrane Biogenesis with a Luciferase-Based Reporter Gene Assay. J Vis Exp. 2008 Sep 7;(19):920. doi: 10.3791/920. PMID: 19066535; PMCID: PMC2872982.

 

Stockinger W, Nohturfft A. Studying phagocytosis by live-cell scintillation proximity assay. Methods Mol Biol. 2008;440:147-55. doi: 10.1007/978-1-59745-178-9_11. PMID: 18369943.

 

Nohturfft A, Zhang SC. Coordination of lipid metabolism in membrane biogenesis. Annu Rev Cell Dev Biol. 2009;25:539-66. doi: 10.1146/annurev.cellbio.24.110707.175344. PMID: 19575637.

 

Trivedi V, Zhang SC, Stockinger W, Nohturfft A. A cell-free scintillation proximity assay for studies on lysosome-to-phagosome targeting. Sci STKE. 2007 Jun 26;2007(392):pl3. doi: 10.1126/stke.3922007pl3. PMID: 17595222.

 

Trivedi V, Zhang SC, Castoreno AB, Stockinger W, Shieh EC, Vyas JM, Frickel EM, Nohturfft A. Immunoglobulin G signaling activates lysosome/phagosome docking. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18226-31. doi: 10.1073/pnas.0609182103. Epub 2006 Nov 16. PMID: 17110435; PMCID: PMC1838734.

 

Stockinger W, Zhang SC, Trivedi V, Jarzylo LA, Shieh EC, Lane WS, Castoreno AB, Nohturfft A. Differential requirements for actin polymerization, calmodulin, and Ca2+ define distinct stages of lysosome/phagosome targeting. Mol Biol Cell. 2006 Apr;17(4):1697-710. doi: 10.1091/mbc.e05-12-1140. Epub 2006 Feb 1. PMID: 16452628; PMCID: PMC1415291.

 

Castoreno AB, Wang Y, Stockinger W, Jarzylo LA, Du H, Pagnon JC, Shieh EC, Nohturfft A. Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13129-34. doi: 10.1073/pnas.0506716102. Epub 2005 Sep 2. PMID: 16141315; PMCID: PMC1201629.

 

Wang Y, Castoreno AB, Stockinger W, Nohturfft A. Modulation of endosomal cholesteryl ester metabolism by membrane cholesterol. J Biol Chem. 2005 Mar 25;280(12):11876-86. doi: 10.1074/jbc.M414676200. Epub 2005 Jan 18. PMID: 15657032; PMCID: PMC1940112.

 

Stockinger W, Castoreno AB, Wang Y, Pagnon JC, Nohturfft A. Real-time analysis of endosomal lipid transport by live cell scintillation proximity assay. J Lipid Res. 2004 Nov;45(11):2151-8. doi: 10.1194/jlr.D400011-JLR200. Epub 2004 Aug 16. PMID: 15314094; PMCID: PMC2041838.

 

Nohturfft A, Losick R. Cell biology. Fats, flies, and palmitate. Science. 2002 May 3;296(5569):857-8. doi: 10.1126/science.1072154. PMID: 11988558.

 

Nohturfft A, Yabe D, Goldstein JL, Brown MS, Espenshade PJ. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell. 2000 Aug 4;102(3):315-23. doi: 10.1016/s0092-8674(00)00037-4. PMID: 10975522.

 

DeBose-Boyd RA, Brown MS, Li WP, Nohturfft A, Goldstein JL, Espenshade PJ. Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell. 1999 Dec 23;99(7):703-12. doi: 10.1016/s0092-8674(00)81668-2. PMID: 10619424.

 

Nohturfft A, DeBose-Boyd RA, Scheek S, Goldstein JL, Brown MS. Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11235-40. doi: 10.1073/pnas.96.20.11235. PMID: 10500160; PMCID: PMC18017.

 

Nohturfft A, Brown MS, Goldstein JL. Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12848-53. doi: 10.1073/pnas.95.22.12848. PMID: 9789003; PMCID: PMC23627.

 

Nohturfft A, Brown MS, Goldstein JL. Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain. J Biol Chem. 1998 Jul 3;273(27):17243-50. doi: 10.1074/jbc.273.27.17243. PMID: 9642295.

 

Sakai J, Nohturfft A, Goldstein JL, Brown MS. Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. J Biol Chem. 1998 Mar 6;273(10):5785-93. doi: 10.1074/jbc.273.10.5785. PMID: 9488713.

 

Ronen A, Broit M, Nohturfft A, Curry J, Glickman BW. Variable aberrant cDNAs in single diphtheria toxin-resistant human fibroblasts. Mutat Res. 1997 Oct 6;379(2):109-15. doi: 10.1016/s0027-5107(97)00168-1. PMID: 9357539.

 

Sakai J, Nohturfft A, Cheng D, Ho YK, Brown MS, Goldstein JL. Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein. J Biol Chem. 1997 Aug 8;272(32):20213-21. doi: 10.1074/jbc.272.32.20213. PMID: 9242699.

 

Skandalis A, da Cruz AD, Curry J, Nohturfft A, Curado MP, Glickman BW. Molecular analysis of T-lymphocyte HPRT- mutations in individuals exposed to ionizing radiation in Goiânia, Brazil. Environ Mol Mutagen. 1997;29(2):107-16. PMID: 9118962.

 

Nohturfft A, Hua X, Brown MS, Goldstein JL. Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13709-14. doi: 10.1073/pnas.93.24.13709. PMID: 8942999; PMCID: PMC19399.

 

Hua X, Nohturfft A, Goldstein JL, Brown MS. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell. 1996 Nov 1;87(3):415-26. doi: 10.1016/s0092-8674(00)81362-8. PMID: 8898195.

 

Saddi V, Curry J, Nohturfft A, Kusser W, Glickman BW. Increased hprt mutant frequencies in Brazilian children accidentally exposed to ionizing radiation. Environ Mol Mutagen. 1996;28(3):267-75. doi: 10.1002/(SICI)1098-2280(1996)28:3<267::AID-EM11>3.0.CO;2-D. PMID: 8908186.

 

Dardalhon M, Nohturfft A, Meniel V, Averbeck D. Repair of DNA double-strand breaks induced in Saccharomyces cerevisiae using different gamma-ray dose-rates: a pulsed-field gel electrophoresis analysis. Int J Radiat Biol. 1994 Mar;65(3):307-14. doi: 10.1080/09553009414550361. PMID: 7908309.

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