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Dr Teck Khong

Senior Lecturer in Clinical Pharmacology
Dr Teck Khong is an academic Clinical Pharmacologist with roles in teaching, research and the NHS
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Overview

Dr Teck Khong is a Consultant and Senior Lecturer in Clinical Pharmacology and Cardiovascular Medicine. He has extensive experience of drug development at all stages of research and of clinical use of medicines at an individual prescribing and at regional policy level; and, has experience in evaluating the use and implementation of new medicines and technologies.

He responsible for the teaching of clinical pharmacology, prescribing and clinical skills to both undergraduate medical and pharmacy students. He has been the Clinical Director of the MPharm Course and has led various innovative developments including for instance the implementation of the award-winning “Red Flags Clinical history-taking” module as well as introducing basic-life support teaching, clinical simulation & prescription workshops, ward-round simulations, drug appraisal and serious incident committee simulations, in continually evolving the course to help students develop their clinical skills for emerging career opportunities in tomorrow’s healthcare economy.

Clinically, Dr Khong works as an internal physician, is one of a few European Society of Hypertension-accredited Hypertension Specialist and co-leads the in-patient Cardiovascular Medicine team and Blood Pressure Unit. He sees see over 1200 hypertension-related consultations a year, including routine out-patient as well as urgent and emergency in-patient cases; and, maintains an active research program in the field of hypertension.

He is responsible for the local St George’s Hospital Guidelines for the Management of Medical Emergencies and is the editor for the related Grey Book

 

Key Roles:

  • MPharm Clinical Director
  • Editor (Grey Book: The St George’s Guidelines for Management of Medical Emergencies and Antibiotic Use)
  • Contributing Editor (Drugs Therapeutics Bulletin, London, UK)
  • Honorary Senior Lecturer (Faculty of Science) at Kingston University

 

 

Dr Khong graduated in Medicine from the University of Dundee, Scotland.

He undertook his junior house-officer rotation on the professorial firm on the Clinical Pharmacology Unit at Ninewells Hospital and during this period was awarded the GlaxoSmithKline House-officer Prize. He went on to complete his postgraduate medical training on the prestigious University of Dundee Ninewells Senior House-officer Medical rotation and became a Member of Royal College of Physicians.

Thereafter, he completed his British Heart Foundation-funded Clinical Research Fellowship and MD thesis in the Blood Pressure Unit at St George’s Hospital Medical School, London and thereafter his training in Clinical Pharmacology and in Internal Medicine at St George’s Hospital.

Dr Khong was appointed as Senior Lecturer and Consultant Physician at St George’s University of London and St George’s Hospital in 2006. He continues to have roles in education, research and in the NHS.

Dr Khong has undertaken his research in the field of hypertension and cardiovascular disease. He has extensive research experience and published widely in clinical hypertension - including being awarded the British Society of Hypertension Junior Investigator Prize, co-authoring the BMA Prize-winning textbook, “Drugs in Cardiology” and contributing to numerous national and international randomised clinical trials in hypertension.

  • Principal Investigator for the Medical Research Foundation & British Heart Foundation-funded AIM-HY clinical trial.
  • Principal Investigator for the SCRATCH-HTN clinical trial.
  • Local investigator for ASTRAL study
  • Research Physician for the ASCOT study
  1. Khong TK, Fok H. Home blood pressure monitoring: what does the evidence say? Drug Ther Bull. 2021;59(8):119-123.
  2. Ratneswaran C, Steier J, Reed K, Khong TK. Electronic Cigarette Advertising Impacts Adversely on Smoking Behaviour Within a London Student Cohort: A Cross-Sectional Structured Survey. Lung. 2019;197(5):533-540.
  3. Mukhtar O, Cheriyan J, Cockcroft JR, Collier D, Coulson JM, Dasgupta I, Faconti L, Glover M, Heagerty AM, Khong TK, Lip GYH, Mander AP, Marchong MN, Martin U, McDonnell BJ, McEniery CM, Padmanabhan S, Saxena M, Sever PJ, Shiel JI, Wych J, Chowienczyk PJ, Wilkinson IB. A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial. Am Heart J. 2018; 204:102-108.
  4. Nichols CM, Povstyan OV, Albert AP, Gordienko DV, Khan O, Vasilikostas G, Khong TK, Wan A, Reddy M, Harhun MI. Vascular smooth muscle cells from small human omental arteries express P2X1 and P2X4 receptor subunits. Purinergic Signal. 2014;10(4):565-72.
  5. Bonomaully M, Khong TK, Fotriadou M, Tully J. Anxiety and depression related to elevated dopamine in a patient with multiple mediastinal paragangliomas. Gen Hosp Psychiatry 2014;36(4):449.e7-8.
  6. Dean SC, Kerry SM, Khong TK, Kerry SR, Oakeshott P. Evaluation of a specialist nurse-led hypertension clinic with consultant backup in two inner city general practices: randomized controlled trial. Fam Pract. 2014; 31(2): 172-9.
  7. Kerry SM, Markus HS, Khong TK, Cloud GC, Tulloch J, Coster D, Ibison J, Oakeshott P. Home blood pressure monitoring with nurse-led telephone support among patients with hypertension and a history of stroke: a community-based randomized controlled trial. CMAJ. 2013; 185(1): 23-31.
  8. Hitchings AW, Baker EH, Khong TK. Making medicines evergreen. BMJ 2012; 345: e7941.
  9. Harhun MI, Huggins CL, Ratnasingham K, Raje D, Moss RF, Szewczyk K, Vasilikostas G, Greenwood IA, Khong TK, Wan A, Reddy M. Resident Phenotypically Modulated Vascular Smooth Muscle Cells in Healthy Human Arteries. J Cell Mol Med. 2012; 16(11): 2802-12.
  10. Ng FL, Davis AJ, Jepps TA, Harhun MI, Yeung SY, Wan A, Reddy M, Melville D, Nardi A, Khong TK, Greenwood IA. Expression and function of the K+ channel KCNQ genes in human arteries. Br J Pharmacol 2011; 162: 42–53
  11. Ng FL, Davis AJ, Jepps TA, Yeung SY, Nardi A, Greenwood IA, Khong TK. KCNQ-encoded Kv7 Voltage-gated Potassium Channels: Presence And Functional Role In Human Vasculature. Journal of Human Hypertension 2010; 24: 692 (Abstract).

(British Hypertension Society Young Investigators Prize 2011 - Oral Presentation)

  1. Kerry S, Markus H, Khong TK, Doshi R, Conroy R, Oakeshott P. Community based trial of home blood pressure monitoring with nurse-led telephone support in patients with stroke or transient ischaemic attack recently discharged from hospital. Trials. 2008; 9:15.
  2. Hussain MB, Püntmann VO, Mayr M, Khong TK, Singer DR. The role of oxidant stress in angiotensin II-mediated contraction of human resistance arteries in the state of health and the presence of cardiovascular disease. Vascul Pharmacol 2006; 45(6): 395-9. ( Circulation 2002; 106 (Suppl II): 172-173.)
  3. Khong TK, Singer DRJ. Adverse drug reactions; strategies for management and prevention. Expert Opinions in Clinical Pharmacotherapy 2002; 3: 1289-300. (Review)
  4. Ziakka S, Belli AM, Khong TK, MacGregor GA, Missouris CG. Percutaneous transluminal renal artery angioplasty: who benefits most? International Journal of Clinical Practice 2002; 56: 649-54.
  5. Khong TK, MacIntyre DO, Sagnella GA, Griffiths JR, MacGregor GA. In vivo skeletal muscle intracellular pH and acid handling in essential hypertension. Journal of Hypertension 2001; 19: 1595-600. (Poster Presentation – International Society of Hypertension Meeting, Chicago 2000).
  6. Khong TK, Sagnella GA, Miller MA, Connor M, Markandu ND, MacGregor GA. Platelet sodium-hydrogen exchanger activity and left ventricular mass. Journal of Human Hypertension 2001; 15(8): 523-7. (Poster presentation - London Hypertension Society Annual Symposium, April 2000).
  7. Khong TK, Missouris CG, Belli AM, MacGregor GA. Regression of atherosclerotic renal artery stenosis with aggressive lipid lowering therapy. Journal of Human Hypertension 2001; 15: 431-3.
  8. Sagnella GA, Khong TK, Miller MA, MacGregor GA. Platelet sodium/hydrogen exchanger activity and renal acid excretion in normotensive and hypertensives. Clinica Chimica Acta 1999; 283: 105-18.
  9. Miller MA, Sagnella GA, Khong TK, Sagnella GA, Markandu ND, MacGregor GA. Differences in urinary acid-base excretion in patients with essential hypertension and in normotensive controls of Afro-Caribbean origin. Journal of Human Hypertension 2000; 14: 455-459
  10. Khong TK, Missouris CG, Murda’h M, MacGregor GA. A survey of the use of lipid lowering therapy after myocardial infarction. Postgraduate Medical Journal 1998; 74: 600-1.
  11. Khong TK, Khong TY. Delayed post-partum hemorrhage: a morphological study of causes and their relationship to other pregnancy disorders. Obstetrics and Gynecology 1993; 82: 17-22.
  12. Lang CC, Coutie WJ, Khong TK, Struthers AD. Dietary sodium loading increases plasma brain natriuretic peptide levels in man. (Rapid Communication) Journal of Hypertension 1991; 9: 779-882.

 

Editorials & Commentaries

  1. Morselli F, Khong TK. Short-term effect of deprescribing antihypertensives in older people. Drug Ther Bull. 2022;60(8):118-119.
  2. Eltayeb A, Khong TK. Treating hypertension with a pill containing very low doses of four antihypertensive agents compared with standard dose irbesartan. Drug Ther Bull. 2022;60(4):56-58.
  3. Khong TK. Tackling overprescribing: striking the right balance. Drug Ther Bull. 2021;59(12):178.
  4. Khong TK, Fok H. Home blood pressure monitoring: what does the evidence say? Drug Ther Bull. 2021;59(8):119-123.
  5. Khong TK, Au Yeung J. Effect of dapagliflozin in patients with heart failure. Drug Ther Bull. 2021;59(6):86-87.
  6. Kimpton J, Khong TK. What role for PCI in stable ischaemic heart disease? Drug Ther Bull. 2021;59(10):150-151.
  7. Magavern E, Khong TK. Effect of dapagliflozin on cardiovascular events in patients with type 2 diabetes. Drug Ther Bull. 2021;59(2):22-23.
  8. Magavern E, Khong TK. Effect of PCI of culprit and non-culprit lesions for patients with STEMI compared with culprit lesion-only PCI. Drug Ther Bull. 2021;59(4):54-55
  9. Khong TK. Hype and hope of bedtime dosing of antihypertensives: better to sleep on it? Drug Ther Bull. 2020;58(12):178.
  10. Khong TK, Kimpton J. Moderate calorie restriction improves cardiometabolic risk factors in healthy individuals. Drug Ther Bull. 2020; 58(9): 135-136.
  11. Page C, Khong TK. Is tramadol associated with an increase in all-cause mortality among patients with osteoarthritis? Drug Ther Bull. 2020; 58(8): 120-121.
  12. Khong TK, Threapleton CJD. Prescribing of anticholinergic medicines to patients initiating dementia medicines. Drug Ther Bull. 2020; 58(6):83-84.
  13. Khong TK, Lall K. No benefit from amitriptyline for chronic low back pain? Drug Ther Bull. 2020; 58(4): 53-54.
  14. Moyo K, Khong TK. High-dose PPI and aspirin as chemoprevention in Barrett's oesophagus. Drug Ther Bull. 2020 Mar;58(3):39-40.
  15. Khong TK, Kimpton J. Intensive antiplatelet therapy with three agents does not reduce risk of another stroke. Drug Ther Bull. 2020; 58(1): 6-7.
  16. Khong TK. Medicines optimisation: time to review fibrates? Drug Ther Bull. 2019; 57(10): 146.
  17. Hughes A, Khong TK. Do oral steroids improve hearing outcomes in children with otitis media with effusion? Drug Ther Bull. 2019; 57(11): 166-167.
  18. Magavern EF, Khong TK. Omega-3 fatty acid supplementation does not prevent serious vascular events in people with diabetes. Drug Ther Bull. 2019; 57(10): 150-151.
  19. Khong TK, Adeyeye E. First-line drugs for hypertension. Drug Ther Bull. 2019; 57(9): 135-13
  20. Khong TK, Threapleton C. Discharging doctors do not reliably predict risk of medication-related harm. Drug Ther Bull. 2018; 56(12): 140
  21. Fok H, Khong TK, Phizackerley D. Conditional Approval: who knows? Drug Ther Bull. 2018;56(12): 140

 

Books

Kaski JC, Haywood C, Mahida S, Baker S, Khong TK, Tamargo J (Editors). Drugs in Cardiology. Oxford, UK: Oxford University Press; 2011.

(1st Prize in Pharmacology in British Medical Association Book Awards 2011)

 

The Stroke Association (£142,693). Community-based trial of home blood pressure monitoring with nurse-led telephone support in patients with stroke or TIA recently discharged from hospital

NHS R&D Support Funds (£10,977). Improvement of Cardiovascular Prevention in Sutton and Merton: Evaluation of a specialist service delivery in the primary care setting

St George’s Charitable Trust Foundation (£3,763). The effects of aspirin on vascular function in patients with hypercholesterolaemia.

Faculty of Medicine Vocational Grant (1992);

Cancer Research Campaign Elective Bursary (1991)

Dr Khong is currently the Clinical Director for and a module leader on the MPharm course run in conjunction with Kingston University. He has been involved with the course since its inception and has and has led various innovative developments including for instance the implementation of the award-winning “Red Flags Clinical history-taking” module as well as introducing basic-life support teaching, clinical simulation & prescription workshops, ward-round simulations, drug appraisal and serious incident committee simulations, in continually evolving the course to help students develop their clinical skills for emerging career opportunities in tomorrow’s healthcare economy.

  • Designed and delivered Pharmacology and Prescribing modules (St George’s Refugee Doctors Course)
  • Designed and delivered Management of Medical Emergencies short course (St George’s University)
  • Led “Introduction to Echocardiography” course for Medical trainees and Allied Healthcare Professionals
  • The British Pharmacological Society (BPS) Steering Group Committee for Computer-Aided Learning

 

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