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Dr Veronica Carroll

Senior Lecturer in Vascular Biology

Dr Veronica Carroll is a Senior Lecturer in Vascular Biology and Course Director for the Intercalated BSc in Basic Medical Sciences.

She teaches widely across undergraduate and postgraduate programmes at St George’s and has held several module and academic leadership roles. She is academic lead for year 3 in Biomedical Science.

Her current research is focused on mechanisms of vessel remodelling in lung diseases. She is developing physiologically relevant cell models to better understand endothelial and vascular smooth muscle cell mediated remodelling in pulmonary hypertension.

Dr Carroll obtained her doctoral degree in natural sciences at the Department of Vascular Biology and Thrombosis Research at the Medical University of Vienna. She subsequently held postdoctoral positions at Imperial College School of Medicine, the Weatherall Institute of Molecular Medicine at Oxford University, and the Institute of Cancer Research. The main focus of her postdoctoral work was understanding the mechanisms, imaging and targeting of tumour angiogenesis.

Veronica was appointed to Lecturer at St George’s in 2013 and Senior Lecturer in Vascular Biology in 2017 with a focus on teaching and research. She has taught widely across St George’s undergraduate programmes and has held substantive academic and administrative leadership roles. Her current research interests are in understanding mechanisms of vascular remodelling in lung diseases with a focus on hypoxia-mediated gene regulation in pulmonary hypertension.

Dr Carroll’s current research interests are in understanding the mechanisms of vascular remodelling in pulmonary hypertension. Vessel remodelling arises from changes to endothelial, smooth muscle and adventitial cells of pulmonary arterioles, ultimately leading to vessel wall thickening, lumen obliteration, increased vascular resistance and right heart failure. Currently, there are no targeted therapies for PH in patients with underlying lung disorders. Dr Carroll’s research aims to understand the mechanisms that give rise to PH to enable the identification of new therapeutic targets for this fatal disease.

The research is focused on hypoxia-mediated gene regulation, endothelial to mesenchymal transition and fibrotic changes in the vascular wall. Dr Carroll is developing ex vivo cell model systems that mimic pathological oxygen tension and pressures in the lung to better understand vascular cell remodelling in disease.

Dr Carroll is an examiner for internal and external PhD students.

 

Devkumar S, Rodríguez E, Barnes P, Carroll V. DEPTOR downregulation by HIF/DEC1 axis leads to mTOR activation in pulmonary vasculature. 2022 Annual World Congress of the Pulmonary Vascular Research Institute. Pulm Circ. 2022 12:e12153, A101.

Carroll V. The vascular outsiders. Br J Cancer 2022 126:1509-1510

Raghuraman RP, Duffy D, Carroll VA, Manyonda I, Antonios TF. Oxygen therapy in premature low birth weight infants is associated with capillary loss and increases in blood pressure a pilot study. J Hum Hypertens 2020 34:278-285

Doan H, Parsons A, Devkumar S, Selvarajah J, Miralles F, Carroll VA. HIF-mediated suppression of DEPTOR confers resistance to mTOR kinase inhibition in renal cancer. iScience 2019 21:509-520

Charolidi N and Carroll VA. Hypoxia and Pulmonary Hypertension. In Hypoxia and Human Diseases, Dr. Jing Zheng (Ed.), InTech 2017 Ch11:pp211-225

Dr Francesc Miralles, SGUL

Dr Tarek Antonios, SGUL

Prof Anthony Albert, SGUL

Dr Catherine Roberts, SGUL

Professor Peter Barnes, Royal Brompton, Imperial College

Dr Joose Kreutzer, Biogenium, Finland

Dr Carroll is Course Director for the Intercalated BSc and Academic Year 3 Lead for Biomedical Science. She has held several module lead positions and was academic lead for year 2 in Biomedical Science. She teaches widely across undergraduate programmes including Biomedical Science, Medicine (MBBS5), Healthcare Science (Clinical Physiology) and Clinical Pharmacology.

Veronica is organiser for the level 6 module in Cardiovascular and Respiratory Diseases for the Biomedical Science BSc/iBSc course. She supervises undergraduate and postgraduate research project students and the lab regularly hosts European/International placement students undertaking Master’s level research projects.

Dr Carroll holds a Postgraduate Certificate in Academic Practice and is Fellow of the Higher Education Academy.

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